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bemdaneprocel

Phase 3

Parkinsons Disease (PD) | Monoclonal antibody | Neurology |Bayer AG|Last Updated: Jul 9, 2026

Success Probability

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Trial Design

RandomizedDouble-BlindACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment102

FDA Designations

No designations recorded

Clinical trial landscape

bemdaneprocel · 1 trial · 1 indication

Phase 3 1
NCT06944522A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's DiseaseParkinsons Disease (PD)
RECRUITING102 Analytics
PHASE3RECRUITING
A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease
Parkinsons Disease (PD)Unlock trial analytics

Study Endpoints

Primary Endpoints

Change from baseline in PD diary measure of ON-time without troublesome dyskinesia, adjusted for a 16-hour waking day
From baseline to Week 78

Secondary Endpoints

Change from baseline in PD diary measure of OFF-time, adjusted for a 16-hour waking day
From baseline to Week 78
Change from baseline in Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III score in the off-medication state. Part III score can range from 0 to 132, with lower scores being better.
From baseline to Week 78
Change from baseline in Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II score. Part II score can range from 0 to 52, with lower scores being better.
From baseline to Week 78
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Group AACTIVE_COMPARATORBemdaneprocel will be administered on Day 0
Group BSHAM_COMPARATORSham surgery will be performed on Day 0

Interventions

NameTypeDescription
bemdaneprocelBIOLOGICALInvestigational cell therapy comprising midbrain dopaminergic neuron progenitors derived from human embryonic stem cells
Sham surgeryPROCEDURESham surgery will be performed on Day 0
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Eligibility Criteria

Age Range45 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites42

Inclusion Criteria: * Diagnosis of clinically established PD as defined by the International Parkinson and Movement Disorders Society * Individual of any sex ≥45 to ≤75 years of age at informed consent * Robust and clear response to DA therapy as defined by MDS-UPDRS Part III * ≥4 and \<12 years fr...

Countries:United StatesAustraliaCanada
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Frequently asked questions about bemdaneprocel

What is bemdaneprocel used for in Parkinson's Disease?

Bemdaneprocel is an investigational cell therapy being studied for the treatment of Parkinson's Disease (PD). It is currently in Phase 3 clinical development and is not yet approved by regulatory authorities. The therapy is being evaluated in adults with Parkinson's Disease to assess its efficacy and safety.

What does bemdaneprocel target?

Bemdaneprocel is a cell therapy, classified under the -cel (cell tx) target class. As a cell-based treatment, it is designed to replace or repair damaged cells in the brain associated with Parkinson's Disease. The specific molecular target is not disclosed in the available information.

Who makes bemdaneprocel?

Bemdaneprocel is being developed by Bayer AG, a multinational pharmaceutical company. Bayer AG is publicly traded under the ticker symbol BAYRY. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational cell therapy for Parkinson's Disease.

What phase is bemdaneprocel in?

Bemdaneprocel is currently in Phase 3 clinical development. It is an investigational therapy, meaning it has not been approved by the FDA or other regulatory agencies. The Phase 3 trial is actively recruiting participants to further evaluate the treatment's efficacy and safety in adults with Parkinson's Disease.

What clinical trials is bemdaneprocel in?

Bemdaneprocel is being studied in a Phase 3 clinical trial registered as NCT06944522. This randomized, double-blind, active-controlled study is investigating the efficacy and safety of bemdaneprocel in adults with Parkinson's Disease. The trial is recruiting participants in the United States, Australia, and Canada, with a planned enrollment of 102 participants.

Is bemdaneprocel the same as any other drug?

Bemdaneprocel is a distinct investigational cell therapy developed by Bayer AG. No alternative names for this drug have been identified in the available information. It is being studied specifically for Parkinson's Disease and is currently in Phase 3 clinical trials.