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Valette

Phase 3

Acne Vulgaris | Small molecule | Dermatology |Bayer AG|Last Updated: Jun 6, 2023

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment1,326

FDA Designations

No designations recorded

Clinical trial landscape

Valette · 2 trials · 2 indications

Phase 3 2
NCT00280657Study on Safety and Efficacy of an Oral Contraceptive in Treating Acne PapulopustulosaAcne Vulgaris
COMPLETED1,326 Analytics
NCT00302666Bleeding Pattern StudyOral Contraceptive
COMPLETED1,315 Analytics
PHASE3COMPLETED
Study on Safety and Efficacy of an Oral Contraceptive in Treating Acne Papulopustulosa
Acne VulgarisUnlock trial analytics
PHASE3COMPLETED
Bleeding Pattern Study
Oral ContraceptiveUnlock trial analytics

Study Endpoints

Primary Endpoints

Change in lesions
6 months
Bleeding pattern

Secondary Endpoints

ISGA
6 months
Parameters of safety and tolerability
6 months
Safety, contraceptive efficacy
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Arm 1EXPERIMENTAL -
Arm 2ACTIVE_COMPARATOR -
Arm 3PLACEBO_COMPARATOR -

Interventions

NameTypeDescription
ValetteDRUG1 tablet 0.030 mg ethinylestradiol / 2 mg dienogest + 1 placebo tablet daily for 21 days followed by a 7-day tablet-free interval, oral administration for 6 cycles
DianeDRUG1 tablet 0.035 mg ethinylestradiol / 2 mg cyproterone acetate + 1 placebo tablet daily for 21 days followed by a 7-day tablet-free interval, oral administration for 6 cycles
PlaceboDRUG2 placebo tablets daily for 21 days followed by a 7-day tablet-free interval, oral administration for 6 cycles
Valette (Dienogest/EE30, BAY86-5038)DRUGOral contraceptive extended cycles
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Eligibility Criteria

Age Range16 Years to 45 Years
SexFEMALE
Healthy VolunteersNo
Study Sites62

Inclusion Criteria: * Patients with mild to moderate facial papulopustular acne Exclusion Criteria: * Contraindication against use of hormonal contraceptives

Countries:CzechiaPolandRussiaSlovakiaUkraineGermany
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Frequently asked questions about Valette

What is Valette used for?

Valette is a small molecule oral contraceptive in Phase 3 clinical development. It is also being studied for the treatment of acne vulgaris. The drug is being developed by Bayer AG.

Who makes Valette?

Valette is being developed by Bayer AG, a pharmaceutical company traded under the ticker BAYRY. The drug is currently in Phase 3 clinical development for use as an oral contraceptive and for treating acne vulgaris.

What phase is Valette in?

Valette is in Phase 3 clinical development. It is an investigational drug being studied for use as an oral contraceptive and for the treatment of acne vulgaris. It is not yet approved by regulatory authorities.

What clinical trials is Valette in?

Valette has been studied in two completed Phase 3 clinical trials. One trial, NCT00280657, evaluated the safety and efficacy of Valette in treating acne papulopustulosa in 1326 female participants aged 16 years and older. Another trial, NCT00302666, was a bleeding pattern study in 1315 healthy female participants aged 18 years and older.

Is Valette the same as any other drug?

Valette is the drug name used in clinical trials for this oral contraceptive and acne treatment. No alternative names are listed for Valette in the clinical trial records.