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F-18 FEDAA1106

Phase 1

Positron-Emission Tomography | Small molecule | Neurology |Bayer AG|Last Updated: Jan 8, 2015

Success Probability

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Market & Valuation

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Trial Design

CONTROLLED
Total Trials2
Total Enrollment41

FDA Designations

No designations recorded

Clinical trial landscape

F-18 FEDAA1106 · 2 trials · 3 indications

Phase 1 2
NCT01031199Evaluation of the Positron Emission Tomography (PET) Tracer ZK 6032924 in Patients With Multiple Sclerosis Compared to Healthy VolunteersPositron-Emission Tomography
COMPLETED16 Analytics
NCT01035164Evaluation of ZK 6032924 in Probable Alzheimer's Disease Patients Versus Healthy Volunteers and the Radiation Dosimetry of ZK 6032924 in Healthy VolunteersPositron-Emission Tomography
COMPLETED25 Analytics
PHASE1COMPLETED
Evaluation of the Positron Emission Tomography (PET) Tracer ZK 6032924 in Patients With Multiple Sclerosis Compared to Healthy Volunteers
Positron-Emission TomographyUnlock trial analytics
PHASE1COMPLETED
Evaluation of ZK 6032924 in Probable Alzheimer's Disease Patients Versus Healthy Volunteers and the Radiation Dosimetry of ZK 6032924 in Healthy Volunteers
Positron-Emission TomographyUnlock trial analytics

Study Endpoints

Primary Endpoints

Standard quantification variables derived from 3D PET imaging and brain modeling.
Day of study tracer administration
Visual analysis/description of the uptake and description of brain PET scans.
Day of study tracer administration
Visual analysis/description of the uptake and description of brain PET scans
Day of study tracer administration
Standardized uptake value (SUV) in various cerebral regions/volumes of interest (ROI/VOI) assumed and found to be involved in the pathophysiology of Alzheimer's disease.
Day of study tracer administration

Secondary Endpoints

Standard Safety Parameter: Adverse Event Collection
maximum time from Screening to Follow-up are 37days
Standard Safety Parameter: Electrocardiogram
maximum time from Screening to Follow-up are 37days
Standard Safety Parameter: Safety laboratory
maximum time from Screening to Follow-up are 37days
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeDIAGNOSTIC

Treatment Arms

ArmTypeDescription
Arm 1EXPERIMENTAL -
Arm 2EXPERIMENTAL -
Arm 3EXPERIMENTAL -

Interventions

NameTypeDescription
F-18 FEDAA1106 (BAY85-8101)DRUGMS/CIS patients: Single intravenous bolus of 140 MBq BAY85-8101 ± 15% (ca. 5 mSv), applied mass of tracer \< 5 µg, PET
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Eligibility Criteria

Age Range20 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: Healthy volunteers for brain imaging: * males or females, age 20 - 55 years * assessment of the brain MRI as "normal (age-appropriate)" * absence of any sign of CNS disease, no co-medi cation Patients for brain imaging * males or females, age 20 - 55 years * patients with previ...

Countries:AustraliaSwedenNetherlands
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Frequently asked questions about F-18 FEDAA1106

What is F-18 FEDAA1106 used for?

F-18 FEDAA1106 is an investigational small molecule being developed for use in positron-emission tomography (PET), a type of medical imaging. It is being studied in the context of neurological conditions, specifically multiple sclerosis and Alzheimer's disease, where it may help visualize biological processes in the brain.

Who makes F-18 FEDAA1106?

F-18 FEDAA1106 is being developed by Bayer AG, a German pharmaceutical company. Bayer's stock is traded over-the-counter under the ticker symbol BAYRY.

What phase is F-18 FEDAA1106 in?

F-18 FEDAA1106 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still being studied in clinical trials to evaluate its safety and potential uses.

What clinical trials is F-18 FEDAA1106 in?

F-18 FEDAA1106 has been studied in two completed Phase 1 clinical trials. One trial (NCT01031199) evaluated the PET tracer in patients with multiple sclerosis compared to healthy volunteers. The other trial (NCT01035164) evaluated it in probable Alzheimer's disease patients versus healthy volunteers and assessed radiation dosimetry in healthy volunteers.

Is F-18 FEDAA1106 the same as ZK 6032924?

Yes, F-18 FEDAA1106 is also known as ZK 6032924. Both names refer to the same investigational PET tracer being developed by Bayer AG for imaging in neurological conditions such as multiple sclerosis and Alzheimer's disease.