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Desflurane

Phase 3

Cystoscopes | Small molecule | Other |Baxter International Inc.|Last Updated: Nov 16, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment75
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01219881Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope SurgeryPHASE3 COMPLETED 75Sep 1, 2010Oct 1, 2012Nov 16, 20211 United States
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Study Endpoints
Primary Endpoints
Recovery Time
14 Days

Recovery Time after exposure to desflurane or sevoflurane considering time of emergence from anesthesia

Secondary Endpoints
Difference in Time to Orientation
14 Days
Time to Extubation
14 days
Incidence of Coughing at Extubation, Approximately 10 Minutes After End of Surgery
At extubation, approximately 10 minutes after end of surgery
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelSINGLE_GROUP
PurposeHEALTH_SERVICES_RESEARCH
Treatment Arms
ArmTypeDescription
DesfluraneACTIVE_COMPARATORComparing the effect on recovery time in patients undergoing urological cytoscope surgery under general anesthesia with a laryngeal mask airway (LMA) using Desflurane.
SevofluraneACTIVE_COMPARATORComparing the effect on recovery time in patients undergoing urological cytoscope surgery under general anesthesia with a laryngeal mask airway (LMA) using Sevoflurane.
Interventions
NameTypeDescription
DesfluraneDRUG5.4 to 7.4% desflurane
SevofluraneDRUG1.4 to 2.5% Sevoflurane
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Eligibility Criteria
Age Range50 Years — 75 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Male or female, 50 to 75 years of age. 2. Subjects with an American Society of Anesthesiologist (ASA) physical status of I to III. 3. Subjects able to provide written informed consent to participate in the study. 4. Female subjects who have a negative urine or serum pregnancy...

Countries:United States
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