Recent Updates
Recently added Catalysts

Anti-Adhesion Product

Phase 2

Intraperitoneal Adhesions | Monoclonal antibody | Other |Baxter International Inc.|Last Updated: Aug 4, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindNO_TREATMENT_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment46
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00512356Efficacy and Safety Study of Anti-Adhesion Product in the Prevention of Intraperitoneal AdhesionsPHASE2 COMPLETED 46Dec 1, 2000Apr 1, 2003Aug 4, 20177 Denmark, Poland +1
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Incidence of adhesions around the rectal stump and/or incision line
Secondary Endpoints
Number of subjects with no adhesions
Extent and severity of adhesions around the rectal stump
Extent and severity of adhesions at the incision line
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Investigational product groupEXPERIMENTALAnti-Adhesion Product was applied to the rectal stump and the incision line. Like in the control group, surgical measures to prevent adhesions were also taken, e.g. using minimum traumatizing surgical technique, using powder-free gloves.
Control groupNO_INTERVENTIONOnly surgical measures to prevent adhesions were taken, e.g. using minimum traumatizing surgical technique, using powder-free gloves. No specific additional treatment was applied.
Interventions
NameTypeDescription
Anti-Adhesion ProductBIOLOGICALAnti-Adhesion Product (AAP) is a biological two-component product of human origin. The components of AAP are lyophilized Anti-Adhesion Protein Concentrate (AAPC), containing fibrinogen, lyophilized Thrombin Concentrate (TC) and the respective diluents for the reconstitution of the components.
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites7

Inclusion Criteria: * Written informed consent obtained from the subject or the subject's legally authorized representative prior to study entry * Male or female subjects \> 18 years of age * Subjects undergoing abdominal surgery with the possibility that a rectal stump would remain due to one or m...

Countries:DenmarkPolandSweden
Unlock Eligibility Criteria