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ARO-HIF2

Phase 1

Clear Cell Renal Cell Carcinoma | Small molecule | Oncology |Arrowhead Pharmaceuticals, Inc.|Last Updated: Oct 9, 2025

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment26

FDA Designations

No designations recorded

Clinical trial landscape

ARO-HIF2 · 1 trial · 1 indication

Phase 1 1
NCT04169711Study of ARO-HIF2 in Patients With Advanced Clear Cell Renal Cell CarcinomaClear Cell Renal Cell Carcinoma
COMPLETED26 Analytics
PHASE1COMPLETED
Study of ARO-HIF2 in Patients With Advanced Clear Cell Renal Cell Carcinoma
Clear Cell Renal Cell CarcinomaUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with Adverse Events (AEs) Possibly or Probably Related to Treatment
Up to 2 years from first dose

Secondary Endpoints

Pharmacokinetics (PK) of ARO-HIF2: Maximum Observed Plasma Concentration (Cmax)
Up to Week 2: predose and up to 48 hours postdose
PK of ARO-HIF2: Time to Maximum Plasma Concentration (Tmax)
Up to Week 2: predose and up to 48 hours postdose
PK of ARO-HIF2: Area Under the Plasma Concentration Versus Time Curve from Zero to 4 Hours (AUC0-4)
Up to Week 2: predose and up to 48 hours postdose
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ARO-HIF2EXPERIMENTAL -

Interventions

NameTypeDescription
ARO-HIF2DRUGMultiple doses of ARO-HIF2 by intravenous infusion
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites5

Inclusion Criteria: * Women of childbearing potential must have a negative pregnancy test, cannot be breastfeeding and must be willing to use contraception * Willing to provide written informed consent and to comply with study requirements * Histologically confirmed locally advanced or metastatic c...

Countries:United States
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Frequently asked questions about ARO-HIF2

What is ARO-HIF2 used for?

ARO-HIF2 is an investigational small molecule being developed for the treatment of advanced clear cell renal cell carcinoma. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who is developing ARO-HIF2?

ARO-HIF2 is being developed by Arrowhead Pharmaceuticals, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol ARWR.

What phase is ARO-HIF2 in?

ARO-HIF2 is in Phase 1 clinical development. It is an investigational drug and has not been approved for any use. A Phase 1 study of ARO-HIF2 in patients with advanced clear cell renal cell carcinoma has been completed.

What clinical trials is ARO-HIF2 in?

ARO-HIF2 has one completed clinical trial, NCT04169711, titled 'Study of ARO-HIF2 in Patients With Advanced Clear Cell Renal Cell Carcinoma.' This Phase 1 study enrolled 26 participants in the United States and was not randomized or blinded.

Is ARO-HIF2 the same as any other drug?

ARO-HIF2 is the primary name for this investigational drug. No alternative names have been reported for this asset.