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Testosterone, 1.62% Metered Pump

Phase 3

Primary Hypogonadism | Small molecule | Endocrine |Amneal Pharmaceuticals, Inc.|Last Updated: Jun 26, 2014

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment32

FDA Designations

No designations recorded

Clinical trial landscape

Testosterone, 1.62% Metered Pump · 1 trial · 2 indications

Phase 3 1
NCT02110368Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting ConditionsPrimary Hypogonadism
COMPLETED32 Analytics
PHASE3COMPLETED
Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditions
Primary HypogonadismUnlock trial analytics

Study Endpoints

Primary Endpoints

AUC0-t
Pre-Deose: -1 hour, -0.5 hour and Post-Dose 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 32, 36, 40, 48, and 60 hours

Area under the concentration vs. time curve, from the time of first dosing to the time of the last measured concentration.

AUC0-inf
Pre-Deose: -1 hour, -0.5 hour and Post-Dose 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 32, 36, 40, 48, and 60 hours

Area under the concentration vs. time curve, from time of first dosing to infinity

Cmax
Pre-Deose: -1 hour, -0.5 hour and Post-Dose 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 32, 36, 40, 48, and 60 hours

Maximum reported concentration. Estimated for both baseline

Secondary Endpoints

Tmax
Pre-Deose: -1 hour, -0.5 hour and Post-Dose 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 32, 36, 40, 48, and 60 hours
Kel
Pre-Deose: -1 hour, -0.5 hour and Post-Dose 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 32, 36, 40, 48, and 60 hours
T 1/2
Pre-Deose: -1 hour, -0.5 hour and Post-Dose 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 32, 36, 40, 48, and 60 hours
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
AndroGelACTIVE_COMPARATORAndroGel (testosterone gel) 1.62% Metered-Dose Pump. One actuation 20.25 mg
Testosterone GelEXPERIMENTALTestosterone Topical Gel, 1.62% Metered Pump. One actuation of 20.25 mg.

Interventions

NameTypeDescription
Testosterone Topical Gel, 1.62% Metered PumpDRUG -
AndroGel (testosterone gel) 1.62% Metered-Dose PumpDRUG -
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Eligibility Criteria

Age Range18 Years to 65 Years
SexMALE
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Healthy adult men with hypogonadism with testosterone levels \<250ng/dL * 18 to 65 years of age (inclusive) * Have normal PSA \< 4.0ng/mL * Weighing a minimum of 50 kg and having a body mass index between 18.0 and 38.0 kg/m2. * Good health as determined by medical history and ...

Countries:United States
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Frequently asked questions about Testosterone, 1.62% Metered Pump

What is Testosterone, 1.62% Metered Pump used for?

Testosterone, 1.62% Metered Pump is used for the treatment of Primary Hypogonadism, a condition in which the body does not produce enough testosterone. It is a topical gel delivered via a metered pump and is being developed by Amneal Pharmaceuticals, Inc. for adult male patients with testosterone deficiency.

Who makes Testosterone, 1.62% Metered Pump?

Testosterone, 1.62% Metered Pump is being developed by Amneal Pharmaceuticals, Inc., a company traded on the NYSE under the ticker symbol AMRX. The drug is currently in Phase 3 clinical development for the treatment of Primary Hypogonadism.

What phase is Testosterone, 1.62% Metered Pump in?

Testosterone, 1.62% Metered Pump is in Phase 3 clinical development. It is an investigational drug and has not been approved by the FDA. The drug is being studied for the treatment of Primary Hypogonadism in adult male patients.

What clinical trials is Testosterone, 1.62% Metered Pump in?

Testosterone, 1.62% Metered Pump has one completed clinical trial, NCT02110368, a Phase 3 bioequivalence study. The trial compared the drug to a reference testosterone topical gel in 32 testosterone-deficient adult male subjects under fasting conditions. The study was conducted in the United States.

Is Testosterone, 1.62% Metered Pump the same as a reference testosterone topical gel?

Testosterone, 1.62% Metered Pump is being studied as a potential generic version of a reference testosterone topical gel. In the clinical trial NCT02110368, the drug was compared to a reference product to assess bioequivalence in testosterone-deficient adult male subjects under fasting conditions.