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KSHN001126

Phase 1

Healthy Postmenopausal Women | Small molecule | Other |Amneal Pharmaceuticals, Inc.|Last Updated: Feb 19, 2026

Success Probability

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Market & Valuation

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Trial Design

CONTROLLEDDMC
Total Trials1
Total Enrollment18

FDA Designations

No designations recorded

Clinical trial landscape

KSHN001126 · 1 trial · 1 indication

Phase 1 1
NCT06467201SAD Study to Evaluate Safety, Tolerability, and Pharmacokinetic Profile of AMN1126 in Healthy Post-Menopausal FemalesHealthy Postmenopausal Women
COMPLETED18 Analytics
PHASE1COMPLETED
SAD Study to Evaluate Safety, Tolerability, and Pharmacokinetic Profile of AMN1126 in Healthy Post-Menopausal Females
Healthy Postmenopausal WomenUnlock trial analytics

Study Endpoints

Primary Endpoints

Type, incidence, severity, seriousness, and relatedness of Adverse Events (AEs)
Upto Day 15 after dosing

Adverse events reported after dosing will be evaluated

Number of participants with abnormal laboratory tests results
Upto Day 15 after dosing

Laboratory abnormalities after dosing will be evaluated

Number of participants with abnormal vital signs
Upto Day 15 after dosing
Number of participants with abnormal Electrocardiogram readings
Upto Day 15 after dosing

Impact on QTc interval will be evaluated

Secondary Endpoints

Evaluate the Peak Plasma Concentration (Cmax) of KSHN001126 and its metabolites (KSHN001167, KSHN001168 and Fulvestrant) following ascending single oral doses of KSHN001126
72 hours after dosing
Evaluate the Area under the plasma concentration versus time curve (AUC) of KSHN001126 and its metabolites (KSHN001167, KSHN001168 and Fulvestrant) following ascending single oral doses of KSHN001126
72 hours after dosing
Evaluate the Time to maximum concentration (Tmax) of KSHN001126 and its metabolites (KSHN001167, KSHN001168 and Fulvestrant) following ascending single oral doses of KSHN001126
72 hours after dosing
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSEQUENTIAL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
KSHN001126 150mgEXPERIMENTALLow Dose
KSHN001126 300mgEXPERIMENTALMid Dose
KSHN001126 600mgEXPERIMENTALHigh Dose

Interventions

NameTypeDescription
KSHN001126 150mgDRUG6 subjects will receive single oral dose of 150mg
KSHN001126 300mgDRUG6 subjects will receive single oral dose of 300mg
KSHN001126 600mgDRUG6 subjects will receive single oral dose of 600mg
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Eligibility Criteria

Age Range45 Years to 60 Years
SexFEMALE
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: 1. Able to provide written Informed Consent and communicate with the investigator and comprehend study-related procedures. 2. Healthy, postmenopausal females aged 45 to 60 years old (inclusive), as determined by medical history and physical examination. 3. Body Mass Index at scr...

Countries:United StatesIndia
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Frequently asked questions about KSHN001126

What is KSHN001126?

KSHN001126 is an investigational small molecule being developed by Amneal Pharmaceuticals, Inc. (AMRX). It is currently in Phase 1 clinical development. The drug is being studied in healthy postmenopausal women, and it is not yet approved by the FDA.

What is KSHN001126 used for?

KSHN001126 is being studied for use in healthy postmenopausal women. The ongoing clinical development focuses on evaluating its safety, tolerability, and pharmacokinetic profile in this population. It is an investigational drug and has not been approved for any medical condition.

Who makes KSHN001126?

KSHN001126 is being developed by Amneal Pharmaceuticals, Inc., a company traded on the stock exchange under the ticker symbol AMRX. The drug is currently in Phase 1 clinical trials, and Amneal is the sponsor of the ongoing research.

What phase is KSHN001126 in?

KSHN001126 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by the FDA and is still undergoing clinical trials to assess its safety and tolerability in healthy postmenopausal women.

What clinical trials is KSHN001126 in?

KSHN001126 has one completed clinical trial, identified by the NCT number NCT06467201. This was a single ascending dose (SAD) study that evaluated the safety, tolerability, and pharmacokinetic profile of AMN1126 in healthy post-menopausal females. The trial enrolled 18 participants and took place in the United States and India.

Is KSHN001126 the same as AMN1126?

Yes, KSHN001126 is also known as AMN1126. In the clinical trial NCT06467201, the drug is referred to as AMN1126. Both names refer to the same investigational small molecule being developed by Amneal Pharmaceuticals.