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AVT16

Phase 1

Healthy | Monoclonal antibody | Other |Alvotech|Last Updated: Mar 11, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMC
Total Trials1
Total Enrollment18
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06400719Pilot Study of AVT16 in Healthy Adult SubjectsPHASE1 COMPLETED 18May 29, 2024Nov 6, 2024Mar 11, 20251 New Zealand
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Study Endpoints
Primary Endpoints
Incidence, nature and severity of Treatment Emergent Adverse Events
18 weeks

Safety and Tolerability of AVT16

Secondary Endpoints
Maximum Plasma Concentration (Cmax) of AVT16
18 weeks
Frequency of anti-drug antibodies
18 weeks
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
AVT16EXPERIMENTALSingle intravenous administration of 300mg AVT16, proposed biosimilar to vedolizumab
Interventions
NameTypeDescription
AVT16BIOLOGICALSingle intravenous administration of 300mg of AVT16
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Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male and female subjects aged between 18 and 55 years old inclusive * Medical history without evidence of clinically significant disorder, condition or disease that would pose a risk to subject safety * Haematology and biochemistry tests within normal range Exclusion ...

Countries:New Zealand
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