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RDC-0313

Phase 2

Binge Eating Disorder | Small molecule | Psychiatry |Alkermes plc|Last Updated: Aug 23, 2011

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment69
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01098435ALK33-101: A Study of RDC-0313 (ALKS 33) in Adults With Binge Eating DisorderPHASE2 COMPLETED 69May 1, 2010Jun 1, 2011Aug 23, 20116 United States
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Study Endpoints
Primary Endpoints
Number of participants in each dose group reporting at least 1 treatment-emergent adverse event (TEAE)
6 Weeks

A TEAE is any adverse event (AE), regardless of causality, that either: begins after a participant's first dose of study drug, up to and including the final follow-up visit; or started before a participant's first dose of study drug but worsens in severity after the first dose of study drug, up to and including the final follow-up visit.

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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
RDC-0313 (ALKS 33)EXPERIMENTAL2-capsules taken orally
PlaceboPLACEBO_COMPARATOR2-capsules taken orally
Interventions
NameTypeDescription
RDC-0313 (ALKS 33)DRUGCapsules for daily oral administration
PlaceboDRUGCapsules containing lactose and no active drug for daily oral administration
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Meet the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, text revised (DSM-IV-TR) criteria for a diagnosis of binge eating disorder (BED) * Display greater than or equal to 3 binge eating days per week * Body mass index (BMI) greater than or equal to 30 kg/...

Countries:United States
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