Recent Updates
Recently added Catalysts

RI-001

Phase 2

Upper Respiratory Tract Infection | Monoclonal antibody | Other |ADMA Biologics Inc|Last Updated: Apr 24, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment21
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00632463RI-001 in Immunosuppressed Respiratory Syncytial Virus (RSV) Infected Patients at Risk of Lower Tract RSV IllnessPHASE2 COMPLETED 21Feb 1, 2008May 1, 2010Apr 24, 201319 United States, Canada
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Circulating RI-001 Titer
Study day 18

The primary endpoint of this study was the mean fold titer increase from baseline to Day 18 in circulating serum anti-RSV neutralizing antibody following treatment with RI-001.

Secondary Endpoints
Incidence of RSV Progression From Symptomatic Upper Respiratory Tract Infection to Lower Respiratory Tract Infection.
Study day 33
The Number of Patients Achieving at Least a 4-fold Increase in Serum RSV Neutralizing Antibody Titers
18 Days
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1EXPERIMENTALDose regimen 1
2EXPERIMENTALDose regimen 2
3PLACEBO_COMPARATORPlacebo
Interventions
NameTypeDescription
RI-001BIOLOGICALDose 1
Unlock Study Design Details
Eligibility Criteria
Age Range2 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites19

Inclusion Criteria: 1. An IEC/IRB approved written informed consent signed and dated by the patient or by parent(s) or a legally acceptable representative. The consent form or a specific assent form, where required, will be signed and dated by minors. 2. Documented Bone Marrow Transplant (BMT)/Hema...

Countries:United StatesCanada
Unlock Eligibility Criteria