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iFS Femtosecond Laser System

Phase 2

Corneal Astigmatism | Unknown | Ophthalmology |Abbott Laboratories|Last Updated: Jun 4, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials1
Total Enrollment40
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01348854Safety and Effectiveness of Arcuate Incisions Performed With the iFS Femtosecond Laser SystemPHASE2 COMPLETED 40May 1, 2011Apr 1, 2013Jun 4, 20144 Austria, France +1
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Study Endpoints
Primary Endpoints
Reduction of Astigmatism
6 months

Reduction of astigmatism as determined by manifest refractive cylinder

Secondary Endpoints
Percent of Eyes With Loss of ≥ 2 Lines of Best Spectacle Corrected Visual Acuity (BSCVA)
6 months
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Natural AstigmatismEXPERIMENTALUse of the iFS Femtosecond Laser System to make arcuate incisions to correct naturally occurring corneal astigmatism in eyes with no prior history of ophthalmic surgery. May include eyes with cataracts.
Post Cataract with Residual AstigmatismEXPERIMENTALUse of the iFS Femtosecond Laser System to make arcuate incisions to correct residual astigmatism in eyes that have undergone cataract extraction. May also include eyes with residual astigmatism following implantation of a phakic intraocular lens implanted.
Interventions
NameTypeDescription
iFS Femtosecond Laser SystemDEVICEarcuate incisions placed with the iFS femtosecond laser
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Eligibility Criteria
Age Range21 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites4

Inclusion Criteria: 1. Male or female, of any race, and at least 21 years of age at the time of pre-op exam 2. Corneal astigmatism, as determined by topographic keratometry, of 0.75 D to 4.00 diopters (D) 3. Best Spectacle Corrected Distance Visual Acuity (BSCVA) 1. Group 1: * Natural as...

Countries:AustriaFranceGermany
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