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Moksi

Phase 1

Bioequivalence | Small molecule | Other |Abbott Laboratories|Last Updated: Apr 1, 2022

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment38
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT05307614Bioequivalence Study of Moksi® 400mg Tablet and Avelox® 400mg Tablet (Moxifloxacin) Under Fasting Condition in Healthy Adult Pakistani SubjectsPHASE1 COMPLETED 38Mar 27, 2019Apr 27, 2019Apr 1, 20221 Pakistan
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Study Endpoints
Primary Endpoints
Cmax
0-72 hours post dose

maximum plasma concentration of Moxifloxacin

AUC last (AUC 0-t)
0-72 hours post dose

Area under plasma concentration time curve from zero to time of the last measurable concentration

AUC total (AUC 0-∞)
0-72 hours post dose

area under the plasma concentration-time curve from zero to infinity.

Secondary Endpoints
Tmax
0-72 hours post dose
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
Moksi® 400mg Tablet of AbbottEXPERIMENTALHealthy subjects were orally administered a single dose of Moksi® 400mg Tablet (Moxifloxacin) under fasting condition
Avelox® 400mg Tablet of BayerACTIVE_COMPARATORHealthy subjects were orally administered a single dose of Avelox® 400mg Tablet (Moxifloxacin) under fasting condition.
Interventions
NameTypeDescription
Moksi® 400mg TabletDRUGSingle dose of Moxifloxacin 400 mg Tablet was administered after a 10-hour overnight fast.
Drug: Avelox® 400Mg TabletDRUGSingle dose of Moxifloxacin 400 mg Tablet was administered after a 10-hour overnight fast.
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Eligibility Criteria
Age Range18 Years — 55 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Healthy male volunteers aged 18 to 55 years inclusive. 2. Subjects with a body mass index from 18.5 to 30 kg/m2 (both inclusive). 3. Subjects who are healthy as determined by routine physical examination,including vital sign monitoring (ie, blood pressure, heart rate,and temp...

Countries:Pakistan
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