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FS Laser Surgery, CCC Surgery

Phase 3

Cataract | Unknown | Ophthalmology |Abbott Laboratories|Last Updated: Sep 4, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment30
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01069172Study of the Femtosecond Laser System as Compared to Continuous Curvilinear Capsulorhexis for Cataract SurgeryPHASE3 COMPLETED 30Feb 1, 2010Aug 1, 2010Sep 4, 20141 Dominican Republic
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Study Endpoints
Primary Endpoints
Deviation From Intended Capsulotomy Diameter
Day of Surgery

Capsulotomy diameter measured during surgery for both the experimental and control groups.

Secondary Endpoints
Cumulative Dissipated Energy (CDE)
Day of Surgery
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
FS Laser SurgeryEXPERIMENTALFor femtosecond laser-assisted cataract surgery group (FS Laser Surgery), subjects will receive capsulotomy, lens segmentation and, at investigator discretion, lens softening using the femtosecond laser device. If necessary, ultrasound (U/S) phacoemulsification will also be applied to facilitate removal of the crystalline lens during cataract surgery.
CCC SurgeryACTIVE_COMPARATORFor the continuous curvilinear capsulorhexis (CCC) group (CCC Surgery), subjects will receive the standard of care for CCC and U/S phacoemulsification surgery to facilitate removal of the crystalline lens during cataract surgery.
Interventions
NameTypeDescription
FS Laser SurgeryDEVICEThe Catalys System is an ophthalmic surgical laser system intended for use in cataract surgery to perform capsulotomy, lens segmentation, and lens softening, which are all part of cataract surgery when this femtosecond laser is used.
CCC SurgeryPROCEDURESubjects will receive the standard of care for CCC and U/S cataract surgery to facilitate removal of the crystalline lens. CCC is a procedure that is part of cataract surgery.
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Eligibility Criteria
Age Range50 Years — 80 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Able and willing to comply with the treatment/follow-up schedule and requirements * Able to understand and provide written Informed Consent * ETDRS (Early Treatment of Diabetic Retinopathy Study) visual acuity equal to or worse than 20/32 (best corrected) * Age between 50 and ...

Countries:Dominican Republic
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