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ABT-SLV361

Phase 1

Hypogonadal Males | Small molecule | Endocrine |Abbott Laboratories|Last Updated: Nov 3, 2011

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment -

FDA Designations

No designations recorded

Clinical trial landscape

ABT-SLV361 · 1 trial · 1 indication

Phase 1 1
NCT01346319Study of the Safety, Tolerability and Pharmacokinetics of Testosterone Undecanoate in Hypogonadal Males.Hypogonadal Males
COMPLETED- Analytics
PHASE1COMPLETED
Study of the Safety, Tolerability and Pharmacokinetics of Testosterone Undecanoate in Hypogonadal Males.
Hypogonadal MalesUnlock trial analytics

Study Endpoints

Primary Endpoints

To determine the pharmacokinetics of testosterone after multiple oral doses of ABT-SLV361 in hypogonadal males
During confinement

Blood sample results for testosterone

Secondary Endpoints

To determine the pharmacokinetic of testosterone undecanoate after multiple oral doses of ABT-SLV361 in hypogonadal males
During confinement
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Testosterone undecanoateACTIVE_COMPARATOR -
PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
ABT-SLV361DRUGFor dose groups 1, 2 and 3 medication is taken 1 time per day the first day followed by 2 times per day for 14 days. For dose groups 4 and 5, medication is taken 1 time per day for the first day followed by 2 times per day for 28 days.
placeboDRUGFor dose groups 1, 2 and 3 medication is taken 1 time per day the first day followed by 2 times per day for 14 days. For dose groups 4 and 5, medication is taken 1 time per day for the first day followed by 2 times per day for 28 days.
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Eligibility Criteria

Age Range18 Years to 80 Years
SexMALE
Healthy VolunteersNo
Study Sites1

Inclusion Criteria 1. Serum total testosterone \< 300 ng/dL based on two blood samples obtained between 6 and 10 AM on two separate occasions at least 48 hours apart. Previously documented total testosterone results obtained within 6 weeks of Study Day -2 may be used during screening for subjects n...

Countries:United States
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Frequently asked questions about ABT-SLV361

What is ABT-SLV361 used for?

ABT-SLV361 is an investigational small molecule being developed for the treatment of hypogonadal males. It is an endocrine therapy currently in Phase 1 clinical development. The drug is being studied for its safety, tolerability, and pharmacokinetics in this patient population.

Who makes ABT-SLV361?

ABT-SLV361 is being developed by Abbott Laboratories, a company traded on the New York Stock Exchange under the ticker ABT. The drug is currently in Phase 1 clinical development for hypogonadal males.

What phase is ABT-SLV361 in?

ABT-SLV361 is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. A Phase 1 study of the drug has been completed, evaluating its safety, tolerability, and pharmacokinetics in hypogonadal males.

What clinical trials is ABT-SLV361 in?

ABT-SLV361 has one completed clinical trial registered as NCT01346319, titled "Study of the Safety, Tolerability and Pharmacokinetics of Testosterone Undecanoate in Hypogonadal Males." This Phase 1 study was a randomized, double-blind, placebo-controlled trial conducted in the United States with male participants aged 18 years and older.

Is ABT-SLV361 the same as testosterone undecanoate?

ABT-SLV361 is associated with the compound testosterone undecanoate, as indicated by the clinical trial title for the drug. The Phase 1 study of ABT-SLV361 evaluates testosterone undecanoate in hypogonadal males, suggesting the drug is a form of this testosterone ester.