Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
carboxymethylcellulose based eye formula · 1 trial · 1 indication
Contact lens distance visual acuity was measured for each eye using the LogMAR visual acuity eye chart. The worse eye at Baseline was used for analysis. A change of 0.1 on the LogMAR scale was equivalent to a 1 line change in visual acuity. The following categories are reported: Better=an increase in 2 or more lines, No Change=a change of +/- 1 line, and Worse=a decrease of 2 lines or more.
| Arm | Type | Description |
|---|---|---|
| Carboxymethylcellulose Based Eye Drop Formula | EXPERIMENTAL | 1-2 drops of carboxymethylcellulose based eye drop formula in each eye, a minimum of 4 times a day for 90 days. One of the 4 times a day may be to prepare the contact lens for insertion. |
| REFRESH CONTACTS® | ACTIVE_COMPARATOR | 1-2 drops carboxymethylcellulose sodium based eye drop solution (REFRESH CONTACTS®) in each eye, a minimum of 4 times a day for 90 days. One of the 4 times a day may be to prepare the contact lens for insertion. |
| Name | Type | Description |
|---|---|---|
| carboxymethylcellulose based eye drop formula | DRUG | 1-2 drops of carboxymethylcellulose based eye drop formula in each eye, a minimum of 4 times a day for 90 days. One of the 4 times a day may be to prepare the contact lens for insertion. |
| carboxymethylcellulose sodium based eye drop solution | DRUG | 1-2 drops carboxymethylcellulose sodium based eye drop solution (REFRESH CONTACTS®) in each eye, a minimum of 4 times a day for 90 days. One of the 4 times a day may be to prepare the contact lens for insertion. |
Inclusion Criteria: -Adapted contact wearer with daily usage of at least 6 hours a day, 5 days a week. Exclusion Criteria: * Wearing monovision lenses * Have had refractive surgery within the previous 12 months * Have infection of the eye, eyelids or eye structures.
Carboxymethylcellulose based eye formula is used for contact lens lubrication in patients with contact lens-related discomfort. It is an investigational small molecule being developed by AbbVie Inc. (ABBV) for the ophthalmology therapeutic area. The drug is currently in Phase 3 clinical development.
Carboxymethylcellulose based eye formula is a lubricating eye drop that works by providing moisture and lubrication to the eye surface, which helps reduce friction and discomfort associated with contact lens wear. It does not target a specific molecular receptor but acts as a physical lubricant.
Carboxymethylcellulose based eye formula is being developed by AbbVie Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker ABBV. The drug is currently in Phase 3 clinical trials for contact lens lubrication.
Carboxymethylcellulose based eye formula is in Phase 3 clinical development. It is an investigational drug and has not been approved by regulatory authorities. A Phase 3 clinical trial has been completed to evaluate its safety and efficacy for contact lens lubrication.
Carboxymethylcellulose based eye formula has one completed Phase 3 clinical trial, NCT01844388, which compared the new eye drop formulation with Refresh Contacts®. The trial enrolled 365 participants in the United States and was randomized, double-blind, and active-controlled.
Carboxymethylcellulose based eye formula is not the same as Refresh Contacts. It is a new eye drop formulation being compared against Refresh Contacts® in a clinical trial. Refresh Contacts is an existing product used as an active control in the study, while the carboxymethylcellulose based eye formula is the investigational drug.