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LiRIS low dose and LiRIS high dose

Phase 1

Interstitial Cystitis | Small molecule | Other |AbbVie Inc.|Last Updated: Nov 25, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
CONTROLLEDBiomarker
Total Trials1
Total Enrollment18
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01150565Safety Study of LiRIS in Interstitial Cystitis (IC) PatientsPHASE1 COMPLETED 18Jul 1, 2010Sep 1, 2011Nov 25, 20143 Canada
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Study Endpoints
Primary Endpoints
Cystoscopic examination
Days 1 and 14
Secondary Endpoints
Bladder pain
During and following treatment; study days 1 to 90
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
Treatment Arms
ArmTypeDescription
LiRIS low doseEXPERIMENTALThe first dose group of approximately 10 patients receive low dose LiRIS on Day 1 to Day 14.
LiRIS high doseEXPERIMENTALThe second dose group of approximately 10 patients receive high dose LiRIS on Day 1 to Day 14.
Interventions
NameTypeDescription
LiRIS low dose and LiRIS high doseDRUGDrug delivery system containing lidocaine; LiRIS (low or high dose) is inserted into bladder via cystoscopy on Day 1 and removed via cystoscopy on Day 14. Designed to release lidocaine over a 14 day period.
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Eligibility Criteria
Age Range18 Years — N/A
SexFEMALE
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * Female patients ≥ 18 years of age * If of child-bearing potential, agrees to use effective contraception defined by protocol * Capable of understanding and completing symptom diaries and questionnaires as required in the study * Diagnosed with IC, as defined by protocol criter...

Countries:Canada
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