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Also known as Carboxymethylcellulose Sodium 0.5%
Carboxymethylcellulose 0.5% · 2 trials · 2 indications
Percentage of Subjects Tabulated by Changes in Line Number at Day 90 from Baseline; Visual Acuity measured by LogMar reported as Snellen equivalents. Better: an increase of 2 lines or more in at least one eye; No Change: a change less than +/- 2 lines in both eyes; Worse: a decrease of 2 lines or more in at least one eye.
| Arm | Type | Description |
|---|---|---|
| Carboxymethylcellulose sodium and Glycerin | EXPERIMENTAL | Carboxymethylcellulose sodium and Glycerin based rewetting drop |
| Carboxymethylcellulose sodium | ACTIVE_COMPARATOR | Carboxymethylcellulose sodium based rewetting drop |
| Name | Type | Description |
|---|---|---|
| Carboxymethylcellulose sodium and Glycerin | DEVICE | Eye drops used at least 4 times per day, 1-2 drops in each eye while wearing contact lenses. |
| Carboxymethylcellulose sodium | DEVICE | Eye drops used at least 4 times per day, 1-2 drops in each eye while wearing contact lenses. |
Inclusion Criteria: * Adapted contact lens wearer Exclusion Criteria: * Monovision lens wearer, ocular or systemic disease, pregnant or planning to become pregnant
Carboxymethylcellulose and glycerin is an investigational lubricant eye drop being studied for dry eye and for rewetting during contact lens wear in people with ametropia. It is being developed by AbbVie Inc. (ticker ABBV) and has been tested in completed Phase 2/3 clinical trials.
AbbVie Inc., which trades under the ticker ABBV, is the developer of the carboxymethylcellulose and glycerin lubricant eye drop. The program has been evaluated in two completed Phase 2/3 studies conducted in the United States, one in dry eye and one in contact lens wearers with ametropia.
Carboxymethylcellulose and glycerin is in Phase 2/3 development. Both of its recorded trials, NCT00691197 and NCT00243711, are listed as completed, and no trials are currently active. It is an investigational lubricant eye drop and is not described as an approved product.
Two completed Phase 2/3 trials have studied carboxymethylcellulose and glycerin. NCT00243711 was a multicenter randomized study of an investigational lubricant eye drop in dry eye, enrolling 286 adults. NCT00691197 evaluated safety and acceptability of a rewetting drop with contact lens wear in 246 healthy adult volunteers with ametropia.
Yes. Carboxymethylcellulose and glycerin is also known as carboxymethylcellulose sodium 0.5%, carboxymethylcellulose 0.5%, and carboxymethylcellulose sodium and glycerin. These names refer to the same AbbVie lubricant eye drop formulation studied in dry eye and contact lens rewetting.
Both trials were randomized, double-blind, and active-controlled Phase 2/3 studies in adults aged 18 and older, with participants of all sexes. NCT00243711 enrolled 286 people with dry eye, while NCT00691197 enrolled 246 healthy contact lens wearers with ametropia. Neither study used biomarker-based patient selection.