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APG-1252

Phase 1

EGFR Positive Non-small Cell Lung Cancer | Small molecule | Oncology |Ascentage Pharma Group International - American Depository Shares|Last Updated: Oct 1, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment80
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT04001777A Study of APG-1252 Plus Osimertinib(AZD9291) in EGFR TKI Resistant NSCLC PatientsPHASE1 ACTIVE NOT_RECRUITING 80Jul 4, 2019Jun 1, 2026Oct 1, 20254 China, China +2
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Study Design & Arms
AllocationNA
MaskingNONE
PurposeTREATMENT
Interventions
NameTypeDescription
APG-1252DRUGMultiple dose cohorts, 30 minute IV infusion, weekly for 3 weeks of a cycle with 21days.
Osimertinib Mesylate TabletsDRUGOsimertinib Mesylate Tablets 40mg/80 mg, one time a day until disease progression
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Recent Changes (Last 90 Days)
LOWMay 24, 2026NCT04001777studyFirstPostDate: changed