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REGN20423

Phase 1

Healthy Volunteer | Small molecule | Dermatology |Regeneron Pharmaceuticals, Inc.|Last Updated: Jun 25, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLEDDMC
Total Trials1
Total Enrollment144

FDA Designations

No designations recorded

Clinical trial landscape

REGN20423 · 1 trial · 2 indications

Phase 1 1
NCT07527923First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic DermatitisHealthy Volunteer
RECRUITING144 Analytics
PHASE1RECRUITING
First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis
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Study Endpoints

Primary Endpoints

Occurrence of Treatment Emergent Adverse Events (TEAEs)
Up to 69 weeks
Severity of TEAEs
Up to 69 weeks

Secondary Endpoints

Concentrations of REGN20423 in serum
Up to 57 weeks
Absolute values from baseline of total Interleukin 13 (IL-13)
Up to 52 weeks
Absolute values from baseline of total Immunoglobulin E (IgE)
Up to 52 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Part AEXPERIMENTAL -
Part BEXPERIMENTAL -

Interventions

NameTypeDescription
REGN20423DRUGAdministered per the protocol
PlaceboOTHERAdministered per the protocol
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Part A: Enrolls healthy participants Part B: Enrolls participants with atopic dermatitis Key Inclusion Criteria: Part A: 1. Is judged by the investigator to be in good health based on medical history, physical examination, vital signs, Electrocardiograms (ECGs), and laboratory safety testing at s...

Countries:Belgium
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Recent Changes (Last 90 Days)

LOWJun 25, 2026NCT07527923Status: NOT_YET_RECRUITING → RECRUITING
LOWJun 25, 2026NCT07527923Status: NOT_YET_RECRUITING → RECRUITING
LOWJun 25, 2026NCT07527923Status: NOT_YET_RECRUITING → RECRUITING

Frequently asked questions about REGN20423

What is REGN20423?

REGN20423 is an investigational small molecule being developed by Regeneron Pharmaceuticals for dermatology. It is currently in Phase 1 clinical development, with a first-in-human trial assessing it in healthy adult participants and adults with atopic dermatitis.

What is REGN20423 used for?

REGN20423 is being studied for use in healthy volunteers and in adults with atopic dermatitis. The ongoing Phase 1 trial is evaluating the drug in both populations to assess its safety and tolerability.

Who makes REGN20423?

REGN20423 is being developed by Regeneron Pharmaceuticals, Inc., a biopharmaceutical company traded on NASDAQ under the ticker REGN. The company is conducting a Phase 1 clinical trial of the drug.

What phase is REGN20423 in?

REGN20423 is in Phase 1 clinical development. It is an investigational drug, not yet approved, and is currently being studied in a first-in-human trial that is recruiting participants.

What clinical trials is REGN20423 in?

REGN20423 is being studied in one Phase 1 clinical trial, NCT07527923, titled "First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis." The trial is recruiting in Belgium with an enrollment of 144 participants.

Is REGN20423 being tested in a randomized controlled trial?

Yes, the Phase 1 trial of REGN20423, NCT07527923, is randomized, double-blind, and controlled. It is recruiting healthy volunteers and adults with atopic dermatitis, with a total planned enrollment of 144 participants.