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PF-08052666

Phase 1

Carcinoma, Non-Small-Cell Lung | Small molecule | Oncology |Pfizer, Inc.|Last Updated: Jan 12, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment19
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06466187A Study of SGN-MesoC2 in Advanced Solid TumorsPHASE1 ACTIVE NOT_RECRUITING 19Aug 2, 2024May 1, 2029Jan 12, 202621 United States, Canada
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Study Endpoints
Primary Endpoints
Number of participants with adverse events (AEs)
Through 30-37 days after the last dose of study treatment, 48 Months

An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.

Number of participants with laboratory abnormalities
Through 30-37 days after the last dose of study treatment, 48 Months
Number of participants with dose modifications
Up to 4 months

Frequency of dose modifications (eg, dose delay, treatment interruptions, dose reductions and treatment discontinuations) due to AEs

Number of participants with dose-limiting toxicities (DLTs)
Cycle 1 (21 days)

Incidence of dose-limiting toxicities (DLTs)

Secondary Endpoints
Objective response rate (ORR)
Approximately 1 year 4 months
Best response
Approximately 1 year 4 months
Duration of response (DOR)
Approximately 1 year 4 months
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
PF-08052666EXPERIMENTALPF-08052666 monotherapy
Interventions
NameTypeDescription
PF-08052666DRUGGiven into the vein (IV; intravenously)
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites21

Inclusion Criteria: * Aged 18 years or older. * Histologically- or cytologically-confirmed metastatic or locally advanced unresectable platinum-resistant ovarian cancer, NSCLC, pancreatic ductal adenocarcinoma, endometrial cancer, colorectal cancer, or mesothelioma, who have relapsed or progressed ...

Countries:United StatesCanada
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Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT06466187primaryCompletionDate: changed
LOWMay 24, 2026NCT06466187studyFirstPostDate: changed