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PF-07264660

Phase 1

Healthy | Small molecule | Other |Pfizer, Inc.|Last Updated: Sep 25, 2025

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment12

FDA Designations

No designations recorded

Clinical trial landscape

PF-07264660 · 1 trial · 1 indication

Phase 1 1
NCT06712082A Study to Learn More About the Study Medicine PF-07264660 in Healthy Chinese Adult ParticipantsHealthy
COMPLETED12 Analytics
PHASE1COMPLETED
A Study to Learn More About the Study Medicine PF-07264660 in Healthy Chinese Adult Participants
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Study Endpoints

Primary Endpoints

Maximum Observed Plasma Concentration (Cmax)
Up to Day 181
Time to Reach Maximum Observed Plasma Concentration (Tmax)
Up to Day181
area under the concentration-time curve from time 0 to 336 hours (AUC336)
Up to Day 181
area under the concentration-time curve from time 0 to infinity (AUCinf)
Up to Day 181
area under the concentration-time curve from 0 to time of last measurable concentration (AUClast)
Up to Day 181
Terminal phase half-life (t½)
Up to Day 181
Incidence of treatment-emergent adverse events (TEAEs)
Up to Day 181
Incidence of treatment-emergent serious adverse events (SAEs)
Up to Day 181
Incidence of abnormal and clinically relevant changes in vital signs
Up to Day 181
Incidence of abnormal and clinically relevant changes in electrocardiogram
Up to Day 181
Incidence of abnormal and clinically relevant changes in laboratory assessments
Up to Day 181

Secondary Endpoints

Clearance (CL) of PF-07264660
Up to Day 181
volume of distribution (Vss)
Up to Day 181
mean residence time (MRT)
Up to Day 181
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeOTHER

Treatment Arms

ArmTypeDescription
PF-07264660EXPERIMENTALParticipants will receive a single dose of PF-07264660 via IV infusion
PlaceboPLACEBO_COMPARATORParticipants will receive a single dose of placebo via IV infusion

Interventions

NameTypeDescription
PF-07264660DRUGPF-07264660 solution for injection (single use only)
PlaceboOTHERPlacebo solution for injection (single use only)
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: 1. Healthy male and female participants aged 18 to 65 years. 2. Body mass index (BMI) of 19-27.9 kilogram per meter squared, inclusive, and a total body weight \>50 kilograms (110 pounds). 3. Participants who are willing and able to comply with all scheduled visits, treatment pl...

Countries:China
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Frequently asked questions about PF-07264660

What is PF-07264660?

PF-07264660 is an investigational small molecule being developed by Pfizer, Inc. (PFE). It is currently in Phase 1 clinical development. The drug has been studied in healthy participants, with one completed trial involving 12 individuals in China.

What is PF-07264660 used for?

PF-07264660 is being studied for use in healthy participants. The completed Phase 1 trial was designed to learn more about the study medicine in healthy Chinese adult participants. Its specific therapeutic indication has not been established yet, as it is still in early clinical development.

Who makes PF-07264660?

PF-07264660 is being developed by Pfizer, Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker symbol PFE. The company conducted a Phase 1 clinical trial of the drug in healthy participants in China.

What phase is PF-07264660 in?

PF-07264660 is in Phase 1 clinical development. The drug is investigational and has not been approved by regulatory authorities. One Phase 1 trial has been completed, with no active trials currently listed for this asset.

What clinical trials is PF-07264660 in?

PF-07264660 has one completed clinical trial, identified as NCT06712082. This Phase 1 study, titled "A Study to Learn More About the Study Medicine PF-07264660 in Healthy Chinese Adult Participants," enrolled 12 healthy volunteers in China. The trial was randomized, double-blind, and placebo-controlled.