Recent Updates
Recently added Catalysts

PF-07264660

Phase 2

Atopic Dermatitis | Small molecule | Other |Pfizer, Inc.|Trials Updated: Sep 25, 2025

PF-07264660 development status

Highest phase Phase 2 (NCT05995964)
Phase scored for PFEPhase 1
Registered trials 2 across 1 sponsor since Aug 2023

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment12

FDA Designations

No designations recorded

PF-07264660 clinical trials

PF-07264660 · 1 trial · 1 indication

Phase 1 1
NCT06712082A Study to Learn More About the Study Medicine PF-07264660 in Healthy Chinese Adult ParticipantsHealthy
COMPLETED12 Analytics
PHASE1COMPLETED
A Study to Learn More About the Study Medicine PF-07264660 in Healthy Chinese Adult Participants
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Maximum Observed Plasma Concentration (Cmax)
Up to Day 181
Time to Reach Maximum Observed Plasma Concentration (Tmax)
Up to Day181
area under the concentration-time curve from time 0 to 336 hours (AUC336)
Up to Day 181
area under the concentration-time curve from time 0 to infinity (AUCinf)
Up to Day 181
area under the concentration-time curve from 0 to time of last measurable concentration (AUClast)
Up to Day 181
Terminal phase half-life (t½)
Up to Day 181
Incidence of treatment-emergent adverse events (TEAEs)
Up to Day 181
Incidence of treatment-emergent serious adverse events (SAEs)
Up to Day 181
Incidence of abnormal and clinically relevant changes in vital signs
Up to Day 181
Incidence of abnormal and clinically relevant changes in electrocardiogram
Up to Day 181
Incidence of abnormal and clinically relevant changes in laboratory assessments
Up to Day 181

Secondary Endpoints

Clearance (CL) of PF-07264660
Up to Day 181
volume of distribution (Vss)
Up to Day 181
mean residence time (MRT)
Up to Day 181
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeOTHER

Treatment Arms

ArmTypeDescription
PF-07264660EXPERIMENTALParticipants will receive a single dose of PF-07264660 via IV infusion
PlaceboPLACEBO_COMPARATORParticipants will receive a single dose of placebo via IV infusion

Interventions

NameTypeDescription
PF-07264660DRUGPF-07264660 solution for injection (single use only)
PlaceboOTHERPlacebo solution for injection (single use only)
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: 1. Healthy male and female participants aged 18 to 65 years. 2. Body mass index (BMI) of 19-27.9 kilogram per meter squared, inclusive, and a total body weight \>50 kilograms (110 pounds). 3. Participants who are willing and able to comply with all scheduled visits, treatment pl...

Countries:China
Unlock Eligibility Criteria

Frequently asked questions about PF-07264660

What is PF-07264660?

PF-07264660 is an investigational small molecule drug being developed by Pfizer, Inc. for atopic dermatitis. It is in Phase 1 clinical development. The compound has been studied in a completed Phase 1 trial in healthy adult participants in China.

What is PF-07264660 used for?

PF-07264660 is being developed for the treatment of atopic dermatitis. It is an investigational therapy and has not been approved for any indication. The only completed clinical trial of PF-07264660 enrolled healthy adult volunteers rather than patients with atopic dermatitis.

Who makes PF-07264660?

PF-07264660 is being developed by Pfizer, Inc., which trades on the New York Stock Exchange under the ticker PFE. Pfizer is the sponsor of the clinical program evaluating PF-07264660 in atopic dermatitis.

What phase is PF-07264660 in?

PF-07264660 is in Phase 1 clinical development. One Phase 1 trial has been completed, and no trials are currently active. The drug remains investigational and has not been approved by the FDA or any other regulatory agency for atopic dermatitis or any other indication.

What clinical trials is PF-07264660 in?

PF-07264660 has been evaluated in one completed Phase 1 trial, NCT06712082, titled A Study to Learn More About the Study Medicine PF-07264660 in Healthy Chinese Adult Participants. The trial enrolled 12 healthy adult participants in China and was randomized, double-blind, and placebo-controlled.