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ARO-DIMERPA

Phase 1

Hyperlipidemia; Mixed | Small molecule | Cardiovascular |Arrowhead Pharmaceuticals, Inc.|Last Updated: Aug 18, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment78

FDA Designations

No designations recorded

Clinical trial landscape

ARO-DIMERPA · 1 trial · 1 indication

Phase 1 1
NCT07223658Study of ARO-DIMERPA in Adult Participants With Mixed HyperlipidemiaHyperlipidemia; Mixed
RECRUITING78 Analytics
PHASE1RECRUITING
Study of ARO-DIMERPA in Adult Participants With Mixed Hyperlipidemia
Hyperlipidemia; MixedUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with Treatment-Emergent Adverse Events (TEAEs)
Up to Week 36

Secondary Endpoints

Percent Change from Baseline in Fasting LDL-C
Baseline to Week 36
Percent Change from Baseline in Fasting TGs
Baseline to Week 36
Percent Change from Baseline in Serum apoC-III
Baseline to Week 36
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ARO-DIMERPAEXPERIMENTALARO-DIMERPA in single or multiple ascending doses
PlaceboPLACEBO_COMPARATORPlacebo (normal saline, 0.9%) in single or multiple matching doses

Interventions

NameTypeDescription
ARO-DIMERPADRUGSubcutaneous (SC) injection
PlaceboDRUGCalculated volume to match active treatment by SC injection
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites17

Inclusion Criteria: * Willing to follow diet counseling as per Investigator judgment based on local standard of care * Specific fasting TG, LDL-C, and non-high density lipoprotein cholesterol levels at Screening * Participants of childbearing potential must agree to use highly effective contracepti...

Countries:AustraliaCanadaGeorgiaNew Zealand
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Recent Changes (Last 90 Days)

LOWAug 19, 2026NCT07223658lastUpdatePostDate: changed
LOWAug 19, 2026NCT07223658lastUpdatePostDate: changed
LOWAug 19, 2026NCT07223658lastUpdatePostDate: changed
MEDIUMJul 13, 2026NCT07223658primaryCompletionDate: changed
MEDIUMJul 13, 2026NCT07223658primaryCompletionDate: changed
LOWJun 30, 2026NCT07223658lastUpdatePostDate: changed
LOWJun 30, 2026NCT07223658lastUpdatePostDate: changed
LOWJun 30, 2026NCT07223658lastUpdatePostDate: changed
LOWJun 16, 2026NCT07223658lastUpdatePostDate: changed
LOWJun 16, 2026NCT07223658lastUpdatePostDate: changed
LOWJun 16, 2026NCT07223658lastUpdatePostDate: changed
LOWJun 16, 2026NCT07223658lastUpdatePostDate: changed

Frequently asked questions about ARO-DIMERPA

What is ARO-DIMERPA used for?

ARO-DIMERPA is an investigational small molecule being developed for the treatment of mixed hyperlipidemia, a condition characterized by elevated levels of lipids in the blood. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who is developing ARO-DIMERPA?

ARO-DIMERPA is being developed by Arrowhead Pharmaceuticals, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol ARWR. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational therapy.

What phase is ARO-DIMERPA in?

ARO-DIMERPA is currently in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by the FDA or any other regulatory agency. The ongoing Phase 1 trial is recruiting participants to assess the drug's safety, tolerability, and pharmacokinetics.

What clinical trials is ARO-DIMERPA in?

ARO-DIMERPA is being evaluated in a Phase 1 clinical trial registered as NCT07223658. This randomized, double-blind, placebo-controlled study is recruiting approximately 78 adult participants with mixed hyperlipidemia across Australia, Canada, Georgia, and New Zealand. The trial is currently in the recruiting stage.

Is ARO-DIMERPA the same as any other drug?

No alternative names for ARO-DIMERPA have been disclosed. It is a distinct investigational compound developed by Arrowhead Pharmaceuticals. As of now, it is only known by its code name ARO-DIMERPA and is not marketed under any other brand name.