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Nisoldipine ,

Phase 1

Healthy | Small molecule | Other |Viatris Inc.|Last Updated: Sep 28, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment161
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00985660Bioequivalence Study of Nisoldipine Extended-Release Tablets, 30 mgPHASE1 COMPLETED 78Jun 1, 2007Jul 1, 2007Sep 28, 20091 United States
NCT00979537Single-Dose Fed Bioequivalence Study of Nisoldipine Extended-Release Tablets (40 mg; Mylan) and Sular® Extended-Release Tablets (40 mg; First Horizon) in Healthy VolunteersPHASE1 COMPLETED 83Mar 1, 2007Mar 1, 2007Sep 18, 20091 United States
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Study Endpoints
Primary Endpoints
Area under the plasma concentration time curve
Serial plasma samples collected for up to 72 hours post-dose
Maximum Plasma Concentration
Serial plasma samples collected up to 72 hours post-dose
Bioequivalence
within 30 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
Test:EXPERIMENTALNisoldipine ER Tablets, 30 mg
ReferenceACTIVE_COMPARATORSular Extended-release Tablets, 30 mg
Test: Nisoldipine ER Tablets, 40 mgEXPERIMENTALNisoldipine Extended-release Tablets, 40 mg
Reference: Sular Tablets 40 mgACTIVE_COMPARATORSular Tablets, 40 mg
Interventions
NameTypeDescription
Nisoldipine Extended-release Tablets, 30 mgDRUG1 x 30 mg Tablet under fasting conditions
Sular® Extended Release Tablets, 30 mgDRUG1 x 30 mg Tablet under fasting conditions
Nisoldipine Extended-release Tablets, 40 mgDRUG -
Sular Tablets, 40 mgDRUG -
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Age: 18 years and older. * Sex: Male and/or non-pregnant, non-lactating female. * Women of childbearing potential must have a negative serum beta human chorionic gonadotropin (β-HCG) pregnancy test performed within 21 days prior to the start of the study and on the evening ...

Countries:United States
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