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Alendronate ,

Phase 1

Healthy | Small molecule | Other |Viatris Inc.|Last Updated: Nov 13, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials2
Total Enrollment222
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01012934Fasting Study of Alendronate Sodium Tablets (70 mg) and Fosamax Tablets (70 mg)PHASE1 COMPLETED 110Jul 1, 2002Aug 1, 2002Nov 13, 20091 United States
NCT00983996Fasting Study of Alendronate Sodium Tablets (10 mg) and Fosamax Tablets (10 mg)PHASE1 COMPLETED 112Jun 1, 2002Jul 1, 2002Sep 24, 20091 United States
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Study Endpoints
Primary Endpoints
The 90% confidence interval for the LSMeans ratio of CPEAK, AUCL, and AUCI for the test and reference product should be between 80.00% and 125.00% for the natural log-transformed data.
urine collection up to 36 hours
Bioequivalence
urine collection up to 36 hours
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
1EXPERIMENTALAlendronate Sodium Tablets, 70 mg
2ACTIVE_COMPARATORFosamax Tablets, 70 mg
Interventions
NameTypeDescription
Alendronate Sodium Tablets, 70 mgDRUG1 x 70 mg, single-dose fasting
Fosamax Tablets, 70 mgDRUG1 x 70 mg, single-dose fasting
Alendronate Sodium Tablets, 10 mgDRUG10 mg, single-dose fasting
Fosamax Tablets, 10 mgDRUG10 mg, single-dose fasting
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * healthy, adult subjects, 18 years and older * able to swallow medication Exclusion Criteria: * institutionalized subjects * history of any significant disease * use of any prescription or OTC medications within 14 days of start of study * received any investigational product...

Countries:United States
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