Recent Updates
Recently added Catalysts

-100A-01

Phase 3

Contraception | Small molecule | Other |Viatris Inc.|Last Updated: Jan 28, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment1,319
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT05139121Study of the Safety and Efficacy of MR-100A-01 in Approximately 1200 Healthy Women for up to 13 CyclesPHASE3 COMPLETED 1,319Oct 26, 2021Jan 15, 2025Jan 28, 2025100 United States, Canada +1
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Contraceptive efficacy of MR-100A-01 when used over thirteen 28-day cycles in healthy, post-menarcheal, premenopausal, heterosexually active female subjects of childbearing potential who are at least 16 years of age and at risk of pregnancy
12 months (13 cycles)

The primary efficacy endpoint will be pregnancy rate described by Pearl Index (PI). PI is defined as the number of pregnancies per 100 women-years times 100

Secondary Endpoints
Cycle-wise pregnancy rates over 1 year evaluated using life table analysis [secondary efficacy]
12 months (13 cycles)
Cumulative pregnancy rates over 1 year evaluated using life table analysis [secondary efficacy]
12 months (13 cycles)
Method failure Pearl Index (PI) [secondary efficacy]
12 months (13 cycles)
Unlock Study Endpoints
Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION
Treatment Arms
ArmTypeDescription
MR-100A-01EXPERIMENTALMR-100A-01 is a transdermal delivery system designed to deliver daily hormone exposure of Norelgestromin and Ethinyl Estradiol
Interventions
NameTypeDescription
MR-100A-01DRUGTransdermal contraceptive delivery system
Unlock Study Design Details
Eligibility Criteria
Age Range16 Years — N/A
SexFEMALE
Healthy VolunteersYes
Study Sites100

Inclusion Criteria: 1. Healthy, post-menarcheal and premenopausal women at risk of pregnancy who are at least 16 years of age with no upper age limit. Post-menarcheal female subjects who are at risk of pregnancy, and \<18 years are eligible provided that: 1. Applicable national, state, and loca...

Countries:United StatesCanadaPuerto Rico
Unlock Eligibility Criteria