Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT00977873 | Trial of Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease | PHASE2 | COMPLETED | 240 | — | — | Sep 1, 2009 | Jul 1, 2013 | Feb 4, 2014 | 4 | United Kingdom |
| Arm | Type | Description |
|---|---|---|
| Vigantol oil | ACTIVE_COMPARATOR | Vigantol oil will be administered in 2-monthly oral bolus doses over a period of one year |
| Miglyol oil | PLACEBO_COMPARATOR | Miglyol oil will be administered in 2-monthly oral bolus doses over a period of one year |
| Name | Type | Description |
|---|---|---|
| Cholecalciferol | DIETARY_SUPPLEMENT | Cholecalciferol will be administered as 2-monthly oral bolus doses of Vigantol oil over a period of one year |
| Miglyol oil | DIETARY_SUPPLEMENT | Miglyol oil will be administered in 2-monthly bolus doses over a period of one year |
Principal Inclusion Criteria: * Medical record diagnosis of COPD, emphysema or bronchitis * Post-bronchodilator FEV1 / FVC \< 70% or post-bronchodilator FEV1 / slow VC \< 70% * Post-bronchodilator FEV1 \< 80% predicted * Age ≥ 40 years on day of first dose of IMP * Smoking history ≥ 15 pack-years *...