Recent Updates
Recently added Catalysts

S 95010

Phase 1

Cardiovascular Diseases | Small molecule | Other |Tango Therapeutics, Inc.|Last Updated: Feb 17, 2020

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment49
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03494712Safety of Single Intravenous Administration of S95010 in Human Healthy VolunteersPHASE1 COMPLETED 49Feb 21, 2018Apr 10, 2019Feb 17, 20201 Belgium
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Safety assessed by incidence of Adverse Events
Through study completion, an average of 12 weeks

Safety criterion

Secondary Endpoints
The PK (pharmacokinetic) profile of S 95010 plasma concentration : Area under the plasma concentration-time curve (AUC)
During Hospitalization Period (Day 1, Day 2, Day 3, Day 4) and during ambulatory follow-up period (at Week 2, Week 4 and Week 12)
The PK profile of S 95010 plasma concentration : Plasma half-life
During Hospitalization Period (Day 1, Day 2, Day 3, Day 4) and during ambulatory follow-up period (at Week 2, Week 4 and Week 12)
The PK profile of S 95010 plasma concentration : Maximum plasma concentration (Cmax)
During Hospitalization Period (Day 1, Day 2, Day 3, Day 4) and during ambulatory follow-up period (at Week 2, Week 4 and Week 12)
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
S 95010EXPERIMENTALIncreasing single doses of S 95010 to 5 subjects.
PlaceboPLACEBO_COMPARATORIncreasing single doses of Placebo to 2 subjects.
Interventions
NameTypeDescription
S 95010DRUGSingle administration of S 95010 in healthy volunteers
PlaceboOTHERSingle administration of placebo in healthy volunteers
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 45 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Young healthy male subjects aged between 18 and 45 years (both inclusive) Exclusion Criteria: * Any acute or chronic illness or clinically relevant findings such as livers,kidney, spleen, cardiovascular disease, eye disease in the selection/ inclusion visit examinations * An...

Countries:Belgium
Unlock Eligibility Criteria