Recent Updates
Recently added Catalysts

Agomelatine A

Phase 2

Obsessive Compulsive Disorder | Small molecule | Psychiatry |Tango Therapeutics, Inc.|Last Updated: Jul 25, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment74
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01108393Efficacy of Agomelatine in Patients With Obsessive-Compulsive DisorderPHASE2 COMPLETED 74May 1, 2010Apr 1, 2013Jul 25, 20241 Israel
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Y-BOCS total score
16 weeks

Yale-Brown Obsessive Compulsive scale (Y-BOCS) total score. This scale measures the severity of obsessive and compulsive symptoms from baseline to W16.

Secondary Endpoints
NIMH-OC score
16 weeks
MADRS total score
16 weeks
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Agomelatine AEXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
Agomelatine ADRUGAgomelatine 25 mg film-coated tablet Agomelatine 2x25mg film-coated tablet
PlaceboDRUGPlacebo
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Obsessive Compulsive Disorder (OCD) according to Diagnostic and Statistical Manual, Fourth Edition, Text Revision (DSM-IV-TR), * Y-BOCS total score ≥ 20, * duration of OCD symptoms of at least one year. Exclusion Criteria: * Bipolar disorder, Schizophrenic or Psychotic Disor...

Countries:Israel
Unlock Eligibility Criteria