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Cefprozil for /

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Aug 20, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials3
Total Enrollment91
FDA Designations
No designations recorded
Clinical Trials (3)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00835354Cefprozil for Oral Suspension 250 mg/5 mL, Non-fastingPHASE1 COMPLETED 26May 1, 2004May 1, 2004Aug 20, 20242 United States
NCT00835614Cefprozil for Oral Suspension 250 mg/5 mL, FastingPHASE1 COMPLETED 26Apr 1, 2004Apr 1, 2004Aug 20, 20242 United States
NCT00840866Cefprozil 500 mg Tablets Under Fed ConditionsPHASE1 COMPLETED 39Sep 1, 2003Sep 1, 2003Aug 20, 20241 United States
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Study Endpoints
Primary Endpoints
Cmax (Maximum Observed Concentration)
Blood samples collected over a 12 hour period.

Bioequivalence based on Cmax.

AUC0-t (Area Under the Concentration-time Curve From Time Zero to Time of Last Measurable Concentration)
Blood samples collected over a 12 hour period.

Bioequivalence based on AUC0-t.

AUC0-inf (Area Under the Concentration-time Curve From Time Zero to Infinity)
Blood samples collected over a 12 hour period.

Bioequivalence based on AUC0-inf.

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeOTHER
Treatment Arms
ArmTypeDescription
1EXPERIMENTAL -
2ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
Cefprozil for oral suspension 250 mg/5 mLDRUG1 x 250 mg/5 mL, single-dose fasting
CEFZIL® for Oral Suspension 250 mg/5mLDRUG1 x 250 mg/5 mL, single-dose fasting
cefprozilDRUG500 mg Tablet
Cefzil®DRUG500 mg Tablet
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * All subjects selected for this study will be non-smokers at least 18 years of age. Subjects will have a BMI (body mass index) of 30 or less. * Each subject shall be given a general physical examination within 28 days of initiation of the study. Such examination includes, but i...

Countries:United States
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