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tolevamer -

Phase 3

Clostridium Enterocolitis | Small molecule | Other |Sanofi|Last Updated: Mar 5, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindUNCONTROLLEDBiomarker
Total Trials2
Total Enrollment1,040
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00196794A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C. Difficile-Associated DiarrheaPHASE3 COMPLETED 520Apr 1, 2005Aug 1, 2007Mar 19, 2014138 Australia, Austria +12
NCT00106509A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C.Difficile - Associated DiarrheaPHASE3 COMPLETED 520Mar 1, 2005Feb 1, 2007Mar 5, 2015140 United States, Canada +1
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Study Endpoints
Primary Endpoints
Resolution of diarrhea
Secondary Endpoints
Time to resolution of diarrhea
Recurrence rate
Number of stools
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Interventions
NameTypeDescription
Tolevamer potassium-sodium (GT267-004)DRUG -
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites138

Inclusion Criteria: * 18 years of age and above * The presence of CDAD at the time of enrollment with no other likely etiology for the diarrhea * Less than or equal to 48 hours of treatment with metronidazole, vancomycin or other antibacterial therapy specific for CDAD * Baseline serum potassium \>...

Countries:AustraliaAustriaBelgiumCzechiaDenmarkFranceGermanyIrelandNorwayPortugalSpainSwedenSwitzerlandUnited KingdomUnited StatesCanadaPuerto Rico
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