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Shz QIV , 2 doses

Phase 1

Influenza | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Nov 9, 2022

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
CONTROLLEDBiomarker
Total Trials1
Total Enrollment101
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03430089Safety of a Single Dose or Two Doses of Shenzhen Quadrivalent Influenza VaccinePHASE1 COMPLETED 101Feb 22, 2019Jun 6, 2019Nov 9, 20221 China
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Study Endpoints
Primary Endpoints
Occurrence of serious adverse reactions or Grade 3 non-serious adverse reactions following vaccination with Shz QIV
Within 28 days after vaccination

Number of participants reporting serious adverse reactions and Grade 3 adverse reactions following a vaccination with Shz QIV

Secondary Endpoints
Occurrence of unsolicited systemic AEs reported in the 30 minutes following vaccination/each and any vaccination
Within 30 minutes after vaccination
Occurrence of solicited (prelisted in the subject diary and the electronic Case Report Form [CRF]) injection site reactions and systemic reactions occurring between D0 and D7 after vaccination/each and any vaccination
Up to 7 days after vaccination
Occurrence of unsolicited (spontaneously reported) AEs from D0 to D28 after vaccination/each and any vaccination
Up to 7 days after vaccination
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Group 1: 6 to 35 monthsEXPERIMENTALShz QIV 0.25 mL, 2 doses
Group 2: 3 to 8 yearsEXPERIMENTALShz QIV 0.5 mL, 2 doses
Group 3: 9 to 17 yearsEXPERIMENTALShz QIV 0.5 mL, single dose
Group 4: 18 to 60 yearsEXPERIMENTALShz QIV 0.5 mL, single dose
Group 5: 61 years and olderEXPERIMENTALShz QIV 0.5 mL, single dose
Interventions
NameTypeDescription
Shz QIV 0.25 mL, 2 dosesBIOLOGICALAdministered intramuscularly in the anterolateral aspect of the thigh in infants (aged 6 to 12 months) or into the deltoid muscle (participants aged more than 12 months), 28 days apart.
Shz QIV 0.5 mL, 2 dosesBIOLOGICALAdministered intramuscularly into the deltoid muscle, 28 days apart
Shz QIV 0.5 mL, single doseBIOLOGICALAdministered intramuscularly into the deltoid muscle.
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Eligibility Criteria
Age Range6 Months — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Aged ≥ 6 months on the day of inclusion * For participants aged 6 months through 17 years: Informed consent form has been signed and dated by the parent(s) or another legally acceptable representative, if applicable. Additionally an assent form has been signed and dated by the...

Countries:China
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