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PENTAXIM: DTacP IPV//PRP~T combined vaccine

Phase 3

Diphtheria | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Apr 17, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment370
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01214889Study of PENTAXIM™ Vaccine Versus TETRAXIM™ Vaccine Given With ACTHIB™ Vaccine in South Korean Infants.PHASE3 COMPLETED 370Sep 1, 2010Dec 1, 2011Apr 17, 201214 South Korea
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Study Endpoints
Primary Endpoints
Non-inferiority in terms of seroprotection rates (Diphtheria, Tetanus, Polio types 1, 2 and 3, Polyribosyl Ribitol Phosphate conjugated to Tetanus protein) of PENTAXIM™ Vaccine to the Tetraxim™ and PRP~T conjugate (Act-HIB™) vaccines.
1 month post-dose 3 vaccination
Secondary Endpoints
Information regarding the safety (in terms of solicited injection site and systemic reactions) of PENTAXIM™ vaccine.
Day 0 up to Day 157
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Study Group AEXPERIMENTALParticipants will receive a single dose of DTacP-IPV//PRP T combined vaccine (PENTAXIM™) at age 2, 4 and 6 months.
Study Group BACTIVE_COMPARATORParticipants will receive a dose of DTacP IPV combined vaccine (TETRAXIM™) and PRP-T vaccine (ActHIB™) at 2, 4, and 6 months of age.
Interventions
NameTypeDescription
PENTAXIM™: DTacP IPV//PRP~T combined vaccineBIOLOGICAL0.5 mL, intramuscular
TETRAXIM™: DTacP IPV combined vaccine and ActHIB™: PRP tetanus conjugate vaccineBIOLOGICAL0.5 mL of each vaccine; intramuscular
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Eligibility Criteria
Age Range56 Days — 70 Days
SexALL
Healthy VolunteersYes
Study Sites14

Inclusion Criteria: * Aged 2 months (56 to 70 days) inclusive on the day of inclusion * Born at full term of pregnancy (≥ 37 weeks) and with a birth weight ≥ 2.5 kg * Informed consent form signed by the parent(s) or other legal representative * Able to attend all scheduled visits and to comply with...

Countries:South Korea
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