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2005-2006 trivalent inactivated influenza vaccine

Phase 2

Inactivated Influenza Vaccine | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Jan 28, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment1,375
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00242424Safety and Immunogenicity of Inactivated Influenza Virus Vaccine Among Healthy Children 6-12 Weeks of AgePHASE2 COMPLETED 1,375Sep 1, 2005Sep 1, 2007Jan 28, 20091 United States
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Study Endpoints
Primary Endpoints
To demonstrate the safety of Fluzone vaccine administered to 2-month old children
within 6 months
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
1PLACEBO_COMPARATOR0.25 ml normal saline placebo given as injection to infants at 2 and 3 months of age
2EXPERIMENTAL2005-6 Fluzone, pediatric formulation of trivalent inactivated influenza vaccine (sanofi pasteur) administered to infants at 2 and 3 months of age
Interventions
NameTypeDescription
2005-2006 trivalent inactivated influenza vaccineBIOLOGICALChildren enrolled at 6-12 weeks to receive first dose, 0.25 ml of trivalent inactivated influenza vaccine, 2005-6 pediatric Fluzone formulation (sanofi pastuer), with concomitant routine pediatric vaccines. Second dose administered 4 weeks later.
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Eligibility Criteria
Age Range42 Days — 84 Days
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Age 42 to 84 days on the day of inclusion * Full term (born at \>=36 weeks with birth weight \>=2.5 kg * Considered to be in good health * Parental consent obtained and available * Available for the study duration (6 months) Exclusion Criteria: * Reported allergy to egg prot...

Countries:United States
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