Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT02679235 | Brain Energy and Aging With Triheptanoin | PHASE1 | COMPLETED | 15 | — | — | Apr 1, 2016 | Aug 8, 2018 | Jul 23, 2020 | 1 | Canada |
Global change (average of cortex) in brain glucose uptake as measured by 18F-FDG PET scans PRE vs POST 28±2 days of supplementation
Global change in brain ketone uptake as measured by 11C-acetoacetate PET scans
| Arm | Type | Description |
|---|---|---|
| Triheptanoin | EXPERIMENTAL | Participant will undergo POST Triheptanoin suppementation 1g/kg body weight for 28 days (dose gradually increased each week, starting at, 0.25, 0.5, 0.75 and then 1 g) separated in 4 doses (with eah meal and before night) after a control PRE supplementation imaging protocol. |
| Name | Type | Description |
|---|---|---|
| POST Triheptanoin | DRUG | The target daily dose of triheptanoin will be 1 g/kg/d, or approximately 70 g/d during 28±2 days. It will be divided into four daily doses, one of which will be consumed at each meal and one with an evening snack. |
Inclusion Criteria: * Men and women ≥65 years old; * Score ≥26/30 on the Montreal Cognitive Assessment; -≥10% lower brain glucose uptake in the frontal cortex as determined by PET imaging. Exclusion Criteria: * Score \<26/30 on the Montreal Cognitive Assessment; * Medications likely to affect the...