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Mifepristone

Phase 1

Subclinical Cushing's | Small molecule | Endocrine |Perrigo Company plc|Last Updated: Jan 26, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment6
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00721201Glucocorticoid Receptor Antagonism in Subclinical CushingsPHASE1 COMPLETED 6Nov 1, 2008Mar 1, 2010Jan 26, 20211 United Kingdom
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Study Endpoints
Primary Endpoints
Blood pressure
8 weeks
Secondary Endpoints
Glucose homeostasis
8 weeks
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Interventions
NameTypeDescription
MifepristoneDRUGUse of mifepristone 200mg bd for 8 weeks
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Patients will be eligible for inclusion if: they are males and over 18, lack clinical features classically associated with Cushing's syndrome; have evidence of excess circulating cortisol Exclusion Criteria: * Evidence of local or systemic malignancy; overt Cushing's syndrom...

Countries:United Kingdom
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