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meningococcal B rLP2086 vaccine.

Phase 2

Meningitis, Meningococcal | Monoclonal antibody | Infectious Disease |Pfizer, Inc.|Last Updated: Apr 14, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedPLACEBO_CONTROLLED
Total Trials1
Total Enrollment538
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00808028A Study Evaluating Safety And Immunogenicity Of Meningococcal B Rlp2086 Vaccine In AdolescentsPHASE2 COMPLETED 538Feb 1, 2009Mar 1, 2014Apr 14, 201527 Australia, Poland +1
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Study Endpoints
Primary Endpoints
Percentage of Participants With at Least 4-fold Rise in Recombinant Lipoprotein 2086 (rLP2086) Specific Serum Bactericidal Assay Using Human Complement (hSBA) Titer: Before Vaccination 1 up to 1 Month After Vaccination 2
Before vaccination 1 up to 1 month after vaccination 2
Percentage of Participants With at Least 4-fold Rise in Recombinant Lipoprotein 2086 (rLP2086) Specific Serum Bactericidal Assay Using Human Complement (hSBA) Titer: Before Vaccination 1 up to 1 Month After Vaccination 3
Before vaccination 1 up to 1 month after vaccination 3
Percentage of Participants With Atleast One Adverse Event (AE): Stage 1
Vaccination 1 upto 1 Month after vaccination 3
Percentage of Participants With Atleast One Adverse Event (AE): Stage 2
6 month after vaccination 3 up to 48 months
Secondary Endpoints
Percentage of Participants Achieving Serum Bactericidal Assay Using Human Complement (hSBA) Titer Level Greater Than or Equal To (>=) Prespecified Titer Level
1 month before vaccination 1, 1 month after vaccination 2, 3
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
1EXPERIMENTALdose level 1 rLP2086 vaccine
2EXPERIMENTALdose level 2 rLP2086 vaccine
3EXPERIMENTALdose level 3 rLP2086 vaccine
4PLACEBO_COMPARATORnormal saline (placebo)
Interventions
NameTypeDescription
meningococcal B rLP2086 vaccine.BIOLOGICALvaccine, 0.5 mL, 0 - 2 - 6 to 9 months
normal saline (placebo)OTHERvaccine, 0.5 mL, 0 - 2 - 6 to 9 months
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Eligibility Criteria
Age Range11 Years — 18 Years
SexALL
Healthy VolunteersYes
Study Sites27

Inclusion Criteria: * Healthy male or female subjects between the ages of \>=11 and \<=18 years at the time of enrollment. * Negative urine pregnancy test for all female subjects. * Parent/legal guardian or subject under supervision of the parent/legal guardian must be able to complete all relevant...

Countries:AustraliaPolandSpain
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