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/kg azithromycin , /kg azithromycin IR

Phase 2

Acute Otitis Media | Small molecule | ENT |Pfizer, Inc.|Last Updated: Feb 18, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment38
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00796224Pharmacokinetics Of Azithromycin Immediate Release And Extended Release Formulation In Kids With Acute Otitis MediaPHASE2 COMPLETED 38Dec 1, 2008Feb 1, 2009Feb 18, 20102 Costa Rica
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Study Endpoints
Primary Endpoints
Area Under the Curve From Time Zero to 72 Hours (AUC72Hours)
Predose/0 to 72 Hours

AUC72 = Area under the plasma concentration versus time curve from time zero (pre-dose) to 72 hours.

Secondary Endpoints
Area Under the Curve From Time Zero to Extrapolated Infinite Time (AUC Inf)
Predose/0, 1, 2, 3, 4, 8, 24, 48, 72 hours post-dose
Maximum Observed Plasma Concentration (Cmax) of Azithromycin
Predose/0, 1, 2, 3, 4, 8, 24, 48, 72 hours post-dose
Time to Reach Maximum Observed Plasma Concentration (Tmax) and Plasma Decay Half Life (t1/2) of Azithromycin
Predose/0, 1, 2, 3, 4, 8, 24, 48, 72 hours post-dose
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1.ACTIVE_COMPARATOR60 mg/kg azithromycin ER (Extended Release)arm
2.ACTIVE_COMPARATOR30 mg/kg azithromycin IR (Immediate Release) arm
Interventions
NameTypeDescription
60 mg/kg azithromycin ERDRUGsubjects taken 60 mg/kg azithromycin ER
30 mg/kg azithromycin IRDRUGsubjects taken 30 mg/kg azithromycin IR (Immediate Release)
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Eligibility Criteria
Age Range6 Months — 11 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * Subjects age 6 months to \< 12 years. * Have clinical signs/symptoms of acute otitis media in at least one ear. * Parent(s)/legal guardian(s) provide written informed consent. Exclusion Criteria: * Clinical significant other disease. * Recent use of investigational drugs, pr...

Countries:Costa Rica
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