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Comparator: pranlukast

Phase 3

Rhinitis, Allergic, Seasonal | Small molecule | Other |Organon & Co.|Last Updated: Aug 15, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLED
Total Trials1
Total Enrollment1,375
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00127647An Approved Drug to Study a New Indication for Allergic Rhinitis (0476-327)PHASE3 COMPLETED 1,375Nov 1, 2004Apr 1, 2005Aug 15, 2024 -
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Study Endpoints
Primary Endpoints
Composite Nasal Symptom Score
Secondary Endpoints
Daytime nasal symptom score, Nighttime nasal symptom score
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1EXPERIMENTALmontelukast sodium 5 mg, QD 2-weeks
2EXPERIMENTALmontelukast sodium 10 mg QD 2-weeks
3ACTIVE_COMPARATORPranlukast 225 mg BID 2-weeks
Interventions
NameTypeDescription
montelukast sodiumDRUGmontelukast sodium; 5 mg, 10 mg QD 2-weeks.
Comparator: pranlukastDRUGPranlukast 225 mg BID 2-weeks.
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Eligibility Criteria
Age Range15 Years — 64 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Japanese males and females with a 2-year documented history of seasonal allergic rhinitis symptoms and positive allergy testing (cedar, alder and/or cypress) Exclusion Criteria: * Patients with drug-induced rhinitis or non-allergic rhinitis, or patients who used anti-histami...

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