Recent Updates
Recently added Catalysts

Intravitreal ranibizumab with photodynamic therapy

Phase 2

Age Related Macular Degeneration | Small molecule | Ophthalmology |Novartis AG|Last Updated: Jan 14, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment20
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00413829Immediate Effects of Lucentis® in Conjunction With Photodynamic Therapy With Visudyne® in Exudative AMD(IECOMB)PHASE2 COMPLETED 20Oct 1, 2006Mar 1, 2008Jan 14, 20101 Switzerland
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
incidence of CNV closure one week after combined therapy as assessed with high speed ICG angiography
24 months
Secondary Endpoints
retinal thickness as measured by OCT over time
24 months
change of total lesion area, area of CNV and area of leakage over time as assessed by FA
24 months
mean change of VA from baseline over time
24 months
Unlock Study Endpoints
Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1OTHER -
Interventions
NameTypeDescription
Intravitreal ranibizumab with photodynamic therapyDRUGIntravitreal injection, photodynamic therapy
Unlock Study Design Details
Eligibility Criteria
Age Range50 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Patients 50 years of age or greater * Patients with subfoveal choroidal neovascularization lesions secondary to AMD, either predominantly classic, occult, or minimally classic. * CNV lesion in the study eye is ≤5400 microns in greatest linear dimension * Patients who have a be...

Countries:Switzerland
Unlock Eligibility Criteria