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Comparator: RECOMBIVAX HB

Phase 2

Hepatitis B | Monoclonal antibody | Oncology |Merck & Company, Inc.|Last Updated: Mar 16, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLED
Total Trials1
Total Enrollment566
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00322361Modified Process Hepatitis B Vaccine in Healthy Neonates (V232-056)PHASE2 COMPLETED 566May 1, 2006Jul 1, 2007Mar 16, 2017 -
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Study Endpoints
Primary Endpoints
Geometric mean titer to hepatitis B surface antigen at Month 7
4 weeks Post Dose 3
Secondary Endpoints
Safety and tolerability including use of Vaccination Report Card
Follow-up 14 days Post Vaccination 1, 2, & 3 (Via Vaccination Report Card)
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
1EXPERIMENTALModified Process Hepatitis B Vaccine
2ACTIVE_COMPARATORRecombivax HB™
Interventions
NameTypeDescription
Comparator: RECOMBIVAX HB™BIOLOGICALRECOMBIVAX HB™ 3 x 5-mcg regimen administered via intramuscular injection.
Comparator: Modified process Hepatitis B VaccineBIOLOGICALModified Process Hepatitis B 3 x 5-mcg regimen administered via intramuscular injection.
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Eligibility Criteria
Age Range1 Day — 10 Days
SexALL
Healthy VolunteersYes

Inclusion Criteria: * Healthy male and female full-term (37-42 weeks gestation) neonates (birth to 10 days of age) * Born to mothers with documented negative test for HBsAg within 9 months prior to delivery Exclusion Criteria: * Infant born to mother with no prenatal care * Known or suspected imp...

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