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Ondansetron + Cognitive Behavioral Therapy

Phase 3

Alcohol Dependence | Small molecule | Other |Johnson & Johnson|Last Updated: Feb 7, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment283
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00382642Pharmacological Treatment for AlcoholismPHASE3 COMPLETED 283Jun 1, 2006Dec 1, 2009Feb 7, 20121 United States
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Study Endpoints
Primary Endpoints
Self-reported measure of alcohol consumption (Drinks per Day, Drinks per Drinking Day, Percent Days Abstinent), CDT (ondansetron level), GGT, BAC
Throughout the study
Secondary Endpoints
Pill count, CIWA-Ar, OCDS, Age of onset, SFQ, AASE, ADBS, CGI, TCI, MAC, attendace at psychosocial services
Throughout the study
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
OndansetronEXPERIMENTALArm 1 = Ondansetron 4 mcg/kg b.i.d.+ Cognitive behavioral therapy
PlaceboPLACEBO_COMPARATORArm 2 = Placebo + Cognitive behavioral therapy
Interventions
NameTypeDescription
Ondansetron + Cognitive Behavioral TherapyDRUG13 week outpatient trial
Placebo + Cognitive Behavioral TherapyDRUG13 week outpatient trial
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Males and females who have given written informed consent. * Ages 18 years and above and, must weigh at least 40 Kg and no more than 140 Kg * Good physical health as determined by a complete physical examination, an EKG within normal limits, and laboratory screening tests with...

Countries:United States
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