Recent Updates
Recently added Catalysts

Articular Surface Replacement hip prosthesis

Phase 3

Osteoarthritis, Hip | Unknown | Musculoskeletal |Johnson & Johnson|Last Updated: Mar 1, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment150
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00391937Efficacy of a New Resurfacing Hip ProsthesisPHASE3 COMPLETED 150Oct 1, 2006Jan 1, 2013Mar 1, 20136 Netherlands
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
pre planned position of the femoral component preoperatively (stem-shaft-angle)
within 8 weeks before surgery
actual position of the femoral component postoperatively (stem-shaft-angle)
within one week after surgery
Secondary Endpoints
Harris Hip Score
preoperatively and at 6 weeks, 3, 12, 24 and 36 months postoperatively
Hip pain
preoperatively and at 6 weeks, 3, 12, 24 and 36 months postoperatively
Assessments of the position of femoral component (biomechanical parameters) at the X-rays
preoperatively, during the clinical phase and at 6 weeks, 3, 12, 24 and 36 months postoperatively
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1EXPERIMENTALASR prosthesis placed using CAS
2ACTIVE_COMPARATORASR prosthesis placed by conventional method
Interventions
NameTypeDescription
Articular Surface Replacement (ASR) hip prosthesisDEVICEa DePuy ASR™ primary resurfacing femoral and acetabular component (DePuy International Ltd, Leeds, UK). The cement that will be used is one dose of DePuy SmartSet® GHV 40 gram, a high-viscosity cement with gentamycin (DePuy CMW, Blackpool, UK). Instrumentation includes standard ASR™ instruments and Ci™ Software for DePuy ASR™ System1.0.
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 60 Years
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Men aged ≤ 60 years, and women aged ≤ 55 years * Presence of evident clinical and radiological osteoarthritis of the hip, indicated for a joint replacement surgery Exclusion Criteria: * Evident osteoporosis * Active local or systemic infection * Clinical manifestation of vas...

Countries:Netherlands
Unlock Eligibility Criteria