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IMA 950

Phase 1

CNS Tumor, Adult | Monoclonal antibody | Oncology |Immatics N.V.|Last Updated: Apr 20, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment19
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01920191Phase I/II Trial of IMA950 Multi-peptide Vaccine Plus Poly-ICLC in GlioblastomaPHASE1 COMPLETED 19Aug 1, 2013Mar 1, 2016Apr 20, 20161 Switzerland
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Study Endpoints
Primary Endpoints
Tolerability and safety of IMA950 adjuvanted with Poly-ICLC when given together with temozolomide, using CTCAE V 4.0
up to 2 years
Secondary Endpoints
6, 9 month progression free survival (PFS) using gadolinium enhanced MRI and clinical assessment according to revised RANO criteria
up to 2 years
Overall survival (OS)
up to 2 years
Immunologic endpoints
up to 2 years
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
IMA 950 and Poly ICLCEXPERIMENTAL -
Interventions
NameTypeDescription
IMA 950BIOLOGICAL -
Poly ICLCBIOLOGICAL -
ImmunomonitoringOTHERBlood samples, DTH analysis
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. Histological documentation of glioblastoma. For experimental purposes only, 5 additional grade III astrocytoma may be included (these cases will not be included in the endpoints analysis). 2. Patients must have completed radiation therapy with concomitant temozolomide. 3. HLA...

Countries:Switzerland
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