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Tritanrix-HepB low thio /

Phase 2

Haemophilus Influenzae Type b | Monoclonal antibody | Infectious Disease |GSK plc|Last Updated: Sep 9, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment192
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01061541Immunogenicity, Safety & Reactogenicity of GSK Vaccine Tritanrix™-HepB/Hib2.5 Compared to GSK Vaccine Tritanrix™-HepB/Hiberix™PHASE2 COMPLETED 192Aug 1, 2003Aug 1, 2004Sep 9, 20161 Philippines
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Study Endpoints
Primary Endpoints
anti-PRP antibody concentration above a protocol defined cut-off value.
One month after the third dose of the primary vaccination course.
Secondary Endpoints
anti-HBs antibody concentration
One month after the third dose of the primary vaccination course
anti-PRP antibody concentration
One month after the third dose of the primary vaccination course
anti-tetanus antibody concentration
One month after the third dose of the primary vaccination course
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Group AEXPERIMENTAL -
Group BACTIVE_COMPARATOR -
Interventions
NameTypeDescription
Tritanrix™-HepB low thio /BIOLOGICALOne dose as intramuscular injection at 6, 10 and 14 weeks of age.
Hib 2.5BIOLOGICALOne dose as intramuscular injection at 6, 10 and 14 weeks of age.
Tritanrix™-HepBBIOLOGICALOne dose as intramuscular injection at 6, 10 and 14 weeks of age.
Hiberix™BIOLOGICALOne dose as intramuscular injection at 6, 10 and 14 weeks of age.
Unconjugated Hib vaccine (plain PRP)BIOLOGICALOne dose as intramuscular injection at 10 months of age
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Eligibility Criteria
Age Range6 Weeks — 8 Weeks
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Subjects who the investigator believes that their parents/guardians can and will comply with the requirements of the protocol should be enrolled in the study. * A male or female between, and including, 6 and 8 weeks of age at the time of the first vaccination. * Written inform...

Countries:Philippines
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