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GMI-1359

Phase 1

Healthy | Small molecule | Other |GlycoMimetics, Inc.|Last Updated: Mar 4, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindCONTROLLEDBiomarker
Total Trials1
Total Enrollment58
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02931214Placebo-Controlled Single Dose Study to Evaluate Safety and Pharmacokinetics of GMI-1359 in Healthy VolunteersPHASE1 COMPLETED 58Aug 1, 2016Nov 1, 2018Mar 4, 20191 United States
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Study Endpoints
Primary Endpoints
Treatment related adverse events
15 days

Treatment related adverse events as a measure of safety and tolerability of GMI-1359

Secondary Endpoints
Pharmacokinetics
48 hours
Pharmacodynamics
48 hours
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
GMI-1359EXPERIMENTALDose escalation
PlaceboEXPERIMENTALDose escalation
Interventions
NameTypeDescription
GMI-1359DRUG -
PlaceboDRUG -
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Eligibility Criteria
Age Range19 Years — 60 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Healthy adult male or females, 19-60 years of age (inclusive). 2. Medically healthy with no clinically significant screening results. 3. Females of childbearing potential must either be sexually inactive (abstinent) for 3 months prior to dosing or be using an acceptable birth...

Countries:United States
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