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iStent Inject , Cataract Surgery

Phase 3

Glaucoma | Unknown | Ophthalmology |Glaukos Corporation|Last Updated: May 19, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment164
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01052558GTS400 Stent Implantation in Conjunction With Cataract Surgery in Subjects With Open-angle GlaucomaPHASE3 COMPLETED 164Jan 1, 2010Dec 1, 2013May 19, 201522 United States
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Study Endpoints
Primary Endpoints
Proportion of subjects with 12 month diurnalIOP </= 21 mmHg without use of ocular hypotensive medications for >/= 4 weeks prior to 12 month visit.
12 months
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Cataract Surgery OnlyACTIVE_COMPARATOR -
Treatment with Cataract Surgery & StentsEXPERIMENTALAb interno trabecular micro-bypass stent surgery
Interventions
NameTypeDescription
iStent Inject (GTS400)DEVICESubjects will be randomized to one of two groups. In this case, subjects will undergo cataract surgery with subsequent implantation of GTS400 stents.
Cataract SurgeryPROCEDURESubjects will be randomized to one of two groups. In this case, subjects will undergo cataract surgery only.
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Eligibility Criteria
Age Range18 Years — 90 Years
SexALL
Healthy VolunteersNo
Study Sites22

Inclusion Criteria: * Diagnosed with open-angle glaucoma in the study eye * Subject must be on 1 to 3 glaucoma medications * Subject able and willing to attend follow up visits for two years postop * Subject able and willing to sign informed consent Exclusion Criteria: * Pseudoexfoliative and pig...

Countries:United States
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