Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT06464510 | Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis | PHASE3 | RECRUITING | 2,800 | — | — | Nov 21, 2024 | Sep 1, 2027 | Jan 30, 2026 | 8 | Brazil |
Composite of all-cause mortality or renal replacement therapy within 28 days after randomization.
| Arm | Type | Description |
|---|---|---|
| Early Vasopressin | EXPERIMENTAL | After randomization, vasopressin will be initiated and titrated up to 0.04U/min to maintain the target mean arterial pressure (MAP). Concurrently, norepinephrine will be reduced, with the goal of using the maximum dose of vasopressin and minimizing or eliminating the use of norepinephrine, while still maintaining the target MAP. |
| Norepinephrine plus vasopressin for rescue | ACTIVE_COMPARATOR | After randomization, norepinephrine will be titrated to maintain the target MAP. Vasopressin will be introduced as a rescue strategy only if the norepinephrine dose exceeds 0.5 μg/kg/min. Once vasopressin is initiated, it can be titrated up to 0.04U/min to help maintain the target MAP if the norepinephrine dose remains above 0.5 μg/kg/min. |
| Name | Type | Description |
|---|---|---|
| Early Vasopressin | DRUG | Early Vasopressin group: Vasopressin up to 0.04U/min initiated after randomization. |
| Norepinephrine and Vasopressin for Rescue | DRUG | Norepinephrine and Vasopressin for Rescue group: Vasopressin up to 0.04U/min initiated only if norepinephrine dose exceeds 0.5 μg/kg/min. |
Inclusion Criteria: * Patients with vasopressor dependent sepsis, defined by infection suspicion and antibiotic administration or laboratory confirmed viral infection, plus hypotension with the need of vasopressors for at least one hour; * Admitted or expected to be admitted to the ICU in the next ...