Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT04791943 | Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery | PHASE2 | COMPLETED | 60 | — | — | Nov 16, 2021 | Oct 20, 2025 | Jan 30, 2026 | 1 | United States |
Postoperative consumption of narcotic pain medication will be measured for approximately 72 hours post operatively. Three total surveys will be administered. The surveys will be sent to participants via text message or email and include a link to SurveyMonkey. These surveys will be sent in the morning approximately 1 day, 2 days, and 3 days after surgery. The surveys will query for participant identification and then ask how many tablets of ibuprofen 600mg and hydrocodone-acetaminophen have been taken since the time of surgery or the time of previous survey depending on if the survey is received on Day 1, versus Day 2, and Day 3. The number of narcotic pain medication pills consumed postoperatively will be presented as means and standard deviations by treatment arm.
| Arm | Type | Description |
|---|---|---|
| Experimental Treatment - Melatonin | EXPERIMENTAL | Premedication for three nights with 10mg melatonin |
| Control Treatment - Lactose | PLACEBO_COMPARATOR | Premedication for three nights with lactose capsules |
| Name | Type | Description |
|---|---|---|
| Melatonin 10 MG | DRUG | 3 melatonin 10mg capsules will be given to the treatment arm |
| Lactose pill | DRUG | 3 lactose pills will be provided to the control arm |
Inclusion Criteria: * Subject must have 3-4 partial or full bony impacted third molars requiring surgical extraction under IV sedation * Ages 18-35 * American Society of Anesthesiologists (ASA) Class I or II * English or Spanish speaking patients * Capacity to sign informed consent Exclusion Crite...