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Live-Attenuated influenza Vaccine

Phase 3

Influenza | Monoclonal antibody | Infectious Disease |China Pharma Holdings, Inc.|Last Updated: Sep 14, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment9,000
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02964065A Trial on the Efficacy, Safety and Immunogenicity of Live-Attenuated Influenza Vaccine (LAIV)PHASE3 COMPLETED 9,000Nov 1, 2016 -Sep 14, 20173 China
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Study Endpoints
Primary Endpoints
Percentage of Subjects With Symptomatic, Laboratory-confirmed(RT-PCR/ Virus Culture) Influenza Virus Infection(Vaccine-like Strains)
Through 2 weeks to 1 year post vaccination
Secondary Endpoints
Percentage of Subjects With Symptomatic, Laboratory-confirmed(RT-PCR/ Virus Culture) Influenza Virus Infection(Regardless of Vaccine Match)
Through 2 weeks to 1 year post vaccination
Percentage of Subjects with influenza-like illness caused by Influenza Virus Infection(Laboratory-confirmed by RT-PCR/ Virus Culture)
Through 2 weeks to 1 year post vaccination
Adverse Events Occurring Within 30 Minutes of Administration of Study Vaccine
Through 30 minutes post vaccination
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
LAIVEXPERIMENTALa single dose of Live-Attenuated influenza Vaccine;Dose: 0.2 ml; Each dose contains not less than 6.9 lg EID50 of type A live attenuated influenza virus reassortants(H1N1 and H3N2), and not less than 6.4 lg EID50 of type B live attenuated influenza virus reassortants.
PlaceboPLACEBO_COMPARATORa single dose of Placebo. Inactivated placebo will be identical to LAIV in appearance, ingredients and concentrations, attenuated influenza virus free.
Interventions
NameTypeDescription
Live-Attenuated influenza Vaccine(LAIV)BIOLOGICAL -
PlaceboBIOLOGICAL -
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Eligibility Criteria
Age Range3 Years — 17 Years
SexALL
Healthy VolunteersYes
Study Sites3

Inclusion Criteria: 1. Healthy children and adolescents aged 3-17 years old. 2. Informed consent obtained and signed by subjects or legal guardians prior to screening. Children or adolescents aged 10-17 yrs need sign informed consent by themselves. 3. Willing to participate for the planned duration...

Countries:China
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